CEP152

CEP152
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4N7V
Identifiers
Aliases	CEP152, MCPH4, MCPH9, SCKL5, centrosomal protein 152
External IDs	OMIM: 613529; MGI: 2139083; HomoloGene: 37159; GeneCards: CEP152; OMA:CEP152 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	48,811,146 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	125,467,033 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sperm; ; sural nerve; ; testicle; ; buccal mucosa cell; ; Achilles tendon; ; gonad; ; ventricular zone; ; bone marrow; ; trabecular bone;
	Top expressed in
	choroidal fissure; ; saccule; ; otic vesicle; ; Paneth cell; ; medullary collecting duct; ; otic placode; ; secondary oocyte; ; hematopoietic cell; ; Jacobson's organ; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase binding; protein binding;
Cellular component	deuterosome; cytosol; centriole; nucleoplasm; cytoplasm; pericentriolar material; microtubule organizing center; cytoskeleton; centrosome;
Biological process	cell projection organization; G2/M transition of mitotic cell cycle; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation; centrosome duplication; centriole replication; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	22995
	99100
	ENSG00000103995
	ENSMUSG00000068394
	O94986
	A2AUM9
	NM_001194998; NM_014985
	NM_001081091
	NP_001181927; NP_055800
	NP_001074560
	Wikidata
View/Edit Human	View/Edit Mouse

Centrosomal protein of 152 kDa, also known as Cep152, is a protein that in humans is encoded by the CEP152 gene.^[5] It is the ortholog of the Drosophila melanogaster gene asterless (asl) and both are required for centriole duplication.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103995 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068394 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: centrosomal protein 152kDa".
^ Blachon S, Gopalakrishnan J, Omori Y, Polyanovsky A, Church A, Nicastro D, Malicki J, Avidor-Reiss T (December 2008). "Drosophila asterless and vertebrate Cep152 Are orthologs essential for centriole duplication". Genetics. 180 (4): 2081–94. doi:10.1534/genetics.108.095141. PMC 2600943. PMID 18854586.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103995 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068394 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: centrosomal protein 152kDa".

[pmid18854586-6] Blachon S, Gopalakrishnan J, Omori Y, Polyanovsky A, Church A, Nicastro D, Malicki J, Avidor-Reiss T (December 2008). "Drosophila asterless and vertebrate Cep152 Are orthologs essential for centriole duplication". Genetics. 180 (4): 2081–94. doi:10.1534/genetics.108.095141. PMC 2600943. PMID 18854586.

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