CFAP298

CFAP298
Identifiers
Aliases	CFAP298, C21orf48, CILD26, FBB18, Kur, chromosome 21 open reading frame 59, C21orf59
External IDs	OMIM: 615494; MGI: 1915251; HomoloGene: 10941; GeneCards: CFAP298; OMA:CFAP298 - orthologs
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	90,732,002 bp
RNA expression pattern
	n/a
	Top expressed in
	zygote; ; secondary oocyte; ; neural layer of retina; ; seminiferous tubule; ; spermatid; ; spermatocyte; ; primary oocyte; ; tail of embryo; ; muscle of thigh; ; choroidal fissure;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol; cytoplasm; nucleus; cytoskeleton; cilium; cell projection;
Biological process	cell projection morphogenesis; regulation of cilium movement; cilium assembly;
	Sources:Amigo / QuickGO
Orthologs
	56683
	68001
	ENSG00000159079
	ENSMUSG00000022972
	P57076
	Q8BL95
	NM_017835; NM_021254
	NM_026502
	NP_067077; NP_001337263; NP_001337264; NP_001337265; NP_001337266
	NP_080778
	Wikidata
View/Edit Human	View/Edit Mouse

Cilia- and flagella-associated protein 298 is a protein encoded by CFAP298 gene. It is of interest in part for its association with various diseases. It has been found in high levels in the bone marrow of patients with a negative prognosis of acute myeloid leukemia and an abnormal karyotype.^[4]^[5]^[6] Male Alzheimer's patients have shown a decrease in expression of CFAP298 in their blood cells.^[7]^[8] The CFAP298 gene lies within the critical region of Down Syndrome.^[9] There are no clear paralogs in humans, but the gene has homologues widely conserved among animals, fungi, and algae.

A phylogenetic tree showing the wide conservation c21orf59.

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022972 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bullinger L, Döhner K, Bair E, Fröhling S, Schlenk RF, Tibshirani R, et al. (April 2004). "Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia". The New England Journal of Medicine. 350 (16): 1605–16. doi:10.1056/NEJMoa031046. PMID 15084693. S2CID 13205096.
^ Greiner J, Schmitt M, Li L, Giannopoulos K, Bosch K, Schmitt A, et al. (December 2006). "Expression of tumor-associated antigens in acute myeloid leukemia: Implications for specific immunotherapeutic approaches". Blood. 108 (13): 4109–17. doi:10.1182/blood-2006-01-023127. PMID 16931630. S2CID 15937337.
^ Bullinger L, Ehrich M, Döhner K, Schlenk RF, Döhner H, Nelson MR, van den Boom D (January 2010). "Quantitative DNA methylation predicts survival in adult acute myeloid leukemia". Blood. 115 (3): 636–42. doi:10.1182/blood-2009-03-211003. PMID 19903898. S2CID 13349367.
^ Maes OC, Xu S, Yu B, Chertkow HM, Wang E, Schipper HM (December 2007). "Transcriptional profiling of Alzheimer blood mononuclear cells by microarray". Neurobiology of Aging. 28 (12): 1795–809. doi:10.1016/j.neurobiolaging.2006.08.004. PMID 16979800. S2CID 8185187.
^ Maes OC, Schipper HM, Chertkow HM, Wang E (June 2009). "Methodology for discovery of Alzheimer's disease blood-based biomarkers". The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 64 (6): 636–45. doi:10.1093/gerona/glp045. PMID 19366883.
^ Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG, et al. (May 2010). "Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome". PLOS ONE. 5 (5): e10659. Bibcode:2010PLoSO...510659M. doi:10.1371/journal.pone.0010659. PMC 2873949. PMID 20502642.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000022972 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15084693-4] Bullinger L, Döhner K, Bair E, Fröhling S, Schlenk RF, Tibshirani R, et al. (April 2004). "Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia". The New England Journal of Medicine. 350 (16): 1605–16. doi:10.1056/NEJMoa031046. PMID 15084693. S2CID 13205096.

[pmid16931630-5] Greiner J, Schmitt M, Li L, Giannopoulos K, Bosch K, Schmitt A, et al. (December 2006). "Expression of tumor-associated antigens in acute myeloid leukemia: Implications for specific immunotherapeutic approaches". Blood. 108 (13): 4109–17. doi:10.1182/blood-2006-01-023127. PMID 16931630. S2CID 15937337.

[pmid19903898-6] Bullinger L, Ehrich M, Döhner K, Schlenk RF, Döhner H, Nelson MR, van den Boom D (January 2010). "Quantitative DNA methylation predicts survival in adult acute myeloid leukemia". Blood. 115 (3): 636–42. doi:10.1182/blood-2009-03-211003. PMID 19903898. S2CID 13349367.

[pmid16979800-7] Maes OC, Xu S, Yu B, Chertkow HM, Wang E, Schipper HM (December 2007). "Transcriptional profiling of Alzheimer blood mononuclear cells by microarray". Neurobiology of Aging. 28 (12): 1795–809. doi:10.1016/j.neurobiolaging.2006.08.004. PMID 16979800. S2CID 8185187.

[pmid19366883-8] Maes OC, Schipper HM, Chertkow HM, Wang E (June 2009). "Methodology for discovery of Alzheimer's disease blood-based biomarkers". The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 64 (6): 636–45. doi:10.1093/gerona/glp045. PMID 19366883.

[pmid20502642-9] Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG, et al. (May 2010). "Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome". PLOS ONE. 5 (5): e10659. Bibcode:2010PLoSO...510659M. doi:10.1371/journal.pone.0010659. PMC 2873949. PMID 20502642.

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