| 10 kDa culture filtrate antigen CFP-10 | |||||||
|---|---|---|---|---|---|---|---|
 Structure of the CFP10-ESAT6 complex from M. tuberculosis.[1] | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | esxB | ||||||
| Entrez | 886194 | ||||||
| PDB | 3FAV | ||||||
| RefSeq (Prot) | NP_218391 | ||||||
| UniProt | P0A566 | ||||||
| Other data | |||||||
| Chromosome | genome: 4.35 - 4.35 Mb | ||||||
| |||||||
CFP-10 within bacterial proteins (also known as ESAT-6-like protein esxB or secreted antigenic protein MTSA-10 or 10 kDa culture filtrate antigen CFP-10) is a protein that is encoded by the esxB gene.[2]
CFP-10 is a 10 kDa secreted antigen from Mycobacterium tuberculosis. It forms a 1:1 heterodimeric complex with ESAT-6. Both genes are expressed from the RD1 region of the bacterial genome and play a key role in the virulence of the infection.[3]
- ^ PDB: 1WA8; Renshaw PS, Lightbody KL, Veverka V, Muskett FW, Kelly G, Frenkiel TA, Gordon SV, Hewinson RG, Burke B, Norman J, Williamson RA, Carr MD (July 2005). "Structure and function of the complex formed by the tuberculosis virulence factors CFP-10 and ESAT-6". EMBO J. 24 (14): 2491–8. doi:10.1038/sj.emboj.7600732. PMC 1176459. PMID 15973432.
- ^ "Entrez gene".
- ^ Meher AK, Bal NC, Chary KV, Arora A (Apr 2006). "Mycobacterium tuberculosis H37Rv ESAT-6-CFP-10 compleand biochemical stability". FEBS J. 273 (7): 1445–62. doi:10.1111/j.1742-4658.2006.05166.x. PMID 16689931.