CGMP-dependent protein kinase

protein kinase, cGMP-dependent, type I
Crystallographic structure of the leucine zipper domain of human cGMP dependent protein kinase I beta.[1]
Identifiers
SymbolPRKG1
Alt. symbolsPRKGR1B, PRKG1B
NCBI gene5592
HGNC9414
OMIM176894
RefSeqNM_006258
UniProtQ13976
Other data
LocusChr. 10 q11.2
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StructuresSwiss-model
DomainsInterPro
protein kinase, cGMP-dependent, type II
Identifiers
SymbolPRKG2
NCBI gene5593
HGNC9416
OMIM601591
RefSeqNM_006259
UniProtQ13237
Other data
LocusChr. 4 q13.1-21.1
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StructuresSwiss-model
DomainsInterPro

cGMP-dependent protein kinase or protein kinase G (PKG) is a serine/threonine-specific protein kinase that is activated by cGMP. It phosphorylates a number of biologically important targets and is implicated in the regulation of smooth muscle relaxation, platelet function, sperm metabolism, cell division, and nucleic acid synthesis.

  1. ^ PDB: 3NMD​; Casteel DE, Smith-Nguyen EV, Sankaran B, Roh SH, Pilz RB, Kim C (October 2010). "A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of isoform-specific anchoring". The Journal of Biological Chemistry. 285 (43): 32684–8. doi:10.1074/jbc.C110.161430. PMC 2963381. PMID 20826808.