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CHOP is the acronym for a chemotherapy regimen used in the treatment of non-Hodgkin lymphoma. CHOP consists of:
- Cyclophosphamide, an alkylating agent which damages DNA by binding to it and causing the formation of cross-links
- Hydroxydaunorubicin (also called doxorubicin or adriamycin), an intercalating agent which damages DNA by inserting itself between DNA bases
- Oncovin (vincristine), which prevents cells from duplicating by binding to the protein tubulin
- Prednisone or Prednisolone, which are corticosteroids.
Sometimes the chimeric anti-CD20 monoclonal antibody, rituximab, is added to this treatment regimen to form the R-CHOP regimen.