CHST10

CHST10
Identifiers
Aliases	CHST10, HNK-1ST, HNK1ST, carbohydrate sulfotransferase 10
External IDs	OMIM: 606376; MGI: 2138283; HomoloGene: 21013; GeneCards: CHST10; OMA:CHST10 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	100,417,668 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	38,937,242 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; lateral nuclear group of thalamus; ; middle temporal gyrus; ; frontal pole; ; Brodmann area 10; ; right frontal lobe; ; Brodmann area 9; ; secondary oocyte; ; putamen;
	Top expressed in
	lumbar subsegment of spinal cord; ; visual cortex; ; superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; central gray substance of midbrain; ; cerebellar cortex; ; medial dorsal nucleus; ; dorsal tegmental nucleus; ; nucleus of stria terminalis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; HNK-1 sulfotransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane;
Biological process	cell adhesion; carbohydrate biosynthetic process; carbohydrate metabolic process; proteoglycan biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9486
	98388
	ENSG00000115526
	ENSMUSG00000026080
	O43529
	Q6PGK7
	NM_004854
	NM_145142; NM_001368780
	NP_004845
	NP_660124; NP_001355709
	Wikidata
View/Edit Human	View/Edit Mouse

Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.^[5]^[6]

Cell surface carbohydrates modulate a variety of cellular functions and are typically synthesized in a stepwise manner. HNK1ST plays a role in the biosynthesis of HNK1 (see MIM 151290), a neuronally expressed carbohydrate that contains a sulfoglucuronyl residue.[supplied by OMIM]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115526 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026080 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kang HG, Evers MR, Xia G, Baenziger JU, Schachner M (Sep 2002). "Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases". J Biol Chem. 277 (38): 34766–72. doi:10.1074/jbc.M204907200. PMID 12080076.
^ ^a ^b "Entrez Gene: CHST10 carbohydrate sulfotransferase 10".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115526 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026080 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12080076-5] Kang HG, Evers MR, Xia G, Baenziger JU, Schachner M (Sep 2002). "Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases". J Biol Chem. 277 (38): 34766–72. doi:10.1074/jbc.M204907200. PMID 12080076.

[entrez-6] "Entrez Gene: CHST10 carbohydrate sulfotransferase 10".

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