CHUK

CHUK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BRT
Identifiers
Aliases	CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16, conserved helix-loop-helix ubiquitous kinase, component of inhibitor of nuclear factor kappa B kinase complex, BPS2
External IDs	OMIM: 600664; MGI: 99484; HomoloGene: 979; GeneCards: CHUK; OMA:CHUK - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.31 Start 100,188,300 bp[1] End 100,229,596 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C3|19 36.71 cM Start 44,061,774 bp[2] End 44,095,919 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte middle frontal gyrus Brodmann area 10 islet of Langerhans palpebral conjunctiva germinal epithelium gingival epithelium monocyte gonad Achilles tendon Top expressed in neural layer of retina right kidney seminal vesicula proximal tubule jejunum human kidney liver epithelium of small intestine intestinal villus ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity protein kinase activity IkappaB kinase activity nucleotide binding protein homodimerization activity scaffold protein binding kinase activity protein serine/threonine kinase activity protein binding protein heterodimerization activity ATP binding identical protein binding Cellular component intracellular membrane-bounded organelle nucleoplasm CD40 receptor complex cytoplasmic side of plasma membrane IkappaB kinase complex nucleus cytoplasm cytosol Biological process response to amino acid phosphorylation regulation of tumor necrosis factor-mediated signaling pathway skeletal muscle contraction anatomical structure morphogenesis response to virus cellular response to tumor necrosis factor stimulatory C-type lectin receptor signaling pathway response to hydroperoxide response to organic substance TRIF-dependent toll-like receptor signaling pathway Fc-epsilon receptor signaling pathway protein phosphorylation response to lipopolysaccharide positive regulation of NF-kappaB transcription factor activity stress-activated MAPK cascade response to acetate immune response Rho protein signal transduction positive regulation of I-kappaB kinase/NF-kappaB signaling striated muscle cell differentiation innate immune response inflammatory response T cell receptor signaling pathway response to toxic substance positive regulation of transcription by RNA polymerase II I-kappaB phosphorylation antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent peptidyl-serine phosphorylation tumor necrosis factor-mediated signaling pathway I-kappaB kinase/NF-kappaB signaling cellular response to reactive oxygen species NIK/NF-kappaB signaling positive regulation of transcription, DNA-templated cellular response to cadmium ion cellular response to virus negative regulation of NF-kappaB transcription factor activity MyD88-independent toll-like receptor signaling pathway interleukin-1-mediated signaling pathway response to cholecystokinin Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1147 12675 Ensembl ENSG00000213341 ENSMUSG00000025199 UniProt O15111 Q60680 RefSeq (mRNA) NM_001278 NM_001320928 NM_001162410 NM_007700 RefSeq (protein) NP_001269 NP_001307857 n/a Location (UCSC) Chr 10: 100.19 – 100.23 Mb Chr 19: 44.06 – 44.1 Mb PubMed search [3] [4]
Wikidata
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Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK-α) also known as IKK1 or conserved helix-loop-helix ubiquitous kinase (CHUK) is a protein kinase that in humans is encoded by the CHUK gene.^[5] IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor.^[6] However, IKK-α has many additional cellular targets, and is thought to function independently of the NF-κB pathway to regulate epidermal differentiation.^[7][8]