CKLF-like MARVEL transmembrane domain-containing 5

CKLF-like MARVEL transmembrane domain-containing 5 (CMTM5), previously termed chemokine-like factor superfamily 5 (i.e. CKLFSF5), designates any one of the six protein isoforms (termed CMTM5-v1 to CMTM5-v6) encoded by six different alternative splices of its gene, CMTM5; CMTM5-v1 is the most studied of these isoforms.[1] The CMTM5 gene is located in band 11.2 on the long (i.e. "q") arm of chromosome 14.[2]

The CMTM5 isoforms are members of the CKLF-like MARVEL transmembrane domain-containing family (CMTM). This family consists of 9 proteins although most of them are known to have one or more isoforms. These proteins are: chemokine-like factor (i.e. CLF, the founding member of the family) and CEF-like marvel transmembrane domain-containing 1 through 8 (i.e. CMTM1 through CMTM8).[3] All of these proteins as well as the genes responsible for their production (i.e. CKLF and CMTM1 to CMTM8, respectively) have similar structures[3] but vary in their apparent physiological and pathological functions.[2][4][5][6] Preliminary studies suggest that CMTM5-v1 (which cells commonly secrete to the extracellular spaces such as the blood[7]) or an unspecified CMTM5 isoform has various functions including involvements in regulating the autoimmune system, the development of numerous types of cancers, and the cardiovascular system.

  1. ^ Li M, Luo F, Tian X, Yin S, Zhou L, Zheng S (2020). "Chemokine-Like Factor-Like MARVEL Transmembrane Domain-Containing Family in Hepatocellular Carcinoma: Latest Advances". Frontiers in Oncology. 10: 595973. doi:10.3389/fonc.2020.595973. PMC 7691587. PMID 33282744.
  2. ^ a b Duan HJ, Li XY, Liu C, Deng XL (April 2020). "Chemokine-like factor-like MARVEL transmembrane domain-containing family in autoimmune diseases". Chinese Medical Journal. 133 (8): 951–958. doi:10.1097/CM9.0000000000000747. PMC 7176445. PMID 32195671.
  3. ^ a b Han W, Ding P, Xu M, Wang L, Rui M, Shi S, Liu Y, Zheng Y, Chen Y, Yang T, Ma D (June 2003). "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation". Genomics. 81 (6): 609–17. doi:10.1016/s0888-7543(03)00095-8. PMID 12782130.
  4. ^ Wu J, Li L, Wu S, Xu B (August 2020). "CMTM family proteins 1-8: roles in cancer biological processes and potential clinical value". Cancer Biology & Medicine. 17 (3): 528–542. doi:10.20892/j.issn.2095-3941.2020.0032. PMC 7476098. PMID 32944388.
  5. ^ Wang X, Lei D, Ding J, Liu S, Tao L, Zhang F, Peng J, Xu J (2018). "A DNA-Methylated Sight on Autoimmune Inflammation Network across RA, pSS, and SLE". Journal of Immunology Research. 2018: 4390789. doi:10.1155/2018/4390789. PMC 6109517. PMID 30159339.
  6. ^ Zhang JW, Liu TF, Chen XH, Liang WY, Feng XR, Wang L, Fu SW, McCaffrey TA, Liu ML (August 2017). "Validation of aspirin response-related transcripts in patients with coronary artery disease and preliminary investigation on CMTM5 function". Gene. 624: 56–65. doi:10.1016/j.gene.2017.04.041. PMID 28457985.
  7. ^ Li H, Guo X, Shao L, Plate M, Mo X, Wang Y, Han W (March 2010). "CMTM5-v1, a four-transmembrane protein, presents a secreted form released via a vesicle-mediated secretory pathway". BMB Reports. 43 (3): 182–7. doi:10.5483/bmbrep.2010.43.3.182. PMID 20356458. S2CID 32280803.