CKLF like MARVEL transmembrane domain containing 6

CMTM6
Identifiers
Aliases	CMTM6, CKLFSF6, PRO2219, CKLF like MARVEL transmembrane domain containing 6, ayoube, gourari
External IDs	OMIM: 607889; MGI: 2447165; HomoloGene: 9845; GeneCards: CMTM6; OMA:CMTM6 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	32,502,852 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	114,578,412 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; trabecular bone; ; skin of thigh; ; mucosa of paranasal sinus; ; nipple; ; mononuclear cell; ; monocyte; ; secondary oocyte; ; lactiferous duct; ; epithelium of nasopharynx;
	Top expressed in
	granulocyte; ; right kidney; ; submandibular gland; ; proximal tubule; ; human kidney; ; stroma of bone marrow; ; Paneth cell; ; external carotid artery; ; blood; ; jejunum;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; protein binding;
Cellular component	extracellular exosome; membrane; extracellular space; plasma membrane; integral component of membrane; azurophil granule membrane; specific granule membrane; endosome; early endosome membrane; recycling endosome membrane;
Biological process	chemotaxis; neutrophil degranulation; regulation of signaling receptor activity; protein transport; regulation of protein stability; endocytic recycling;
	Sources:Amigo / QuickGO
Orthologs
	54918
	67213
	ENSG00000091317
	ENSMUSG00000032434
	Q9NX76
	Q9CZ69
	NM_017801
	NM_026036
	NP_060271
	NP_080312
	Wikidata
View/Edit Human	View/Edit Mouse

CKLF like MARVEL transmembrane domain-containing 6 (i.e. CMTM6), previously termed chemokine-like factor superfamily 6 (i.e. CKLFSF6), is a transmembrane protein encoded in humans by the CMTM6 gene (also termed the CKLFSF6, PRO2219, ayoube, or gourari gene). This gene is located in band 22.3 on the short (or "p") arm of chromosome 3.^[5] CMTM6 protein belongs to the CKLF-like MARVEL transmembrane domain-containing family of proteins.^[6] This family consist of 9 member proteins: CKLF and CMTM1 through CMTM8.^[7]^[8] The CMTM family proteins are involved in autoimmune diseases, cardiovascular diseases, the male reproductive system, haematopoiesis, and cancer development.^[8] CMTM6 protein regulates immune responses to normal and abnormal (particularly cancerous) cells.^[9]^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000091317 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032434 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "CMTM6 CKLF like MARVEL transmembrane domain-containing 6 [Homo sapiens (Human)] - Gene - NCBI".
^ Han W, Ding P, Xu M, Wang L, Rui M, Shi S, Liu Y, Zheng Y, Chen Y, Yang T, Ma D (June 2003). "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation". Genomics. 81 (6): 609–17. doi:10.1016/s0888-7543(03)00095-8. PMID 12782130.
^ Lu J, Wu QQ, Zhou YB, Zhang KH, Pang BX, Li L, Sun N, Wang HS, Zhang S, Li WJ, Zheng W, Liu W (2016). "Cancer Research Advance in CKLF-like MARVEL Transmembrane Domain-Containing Member Family (Review)". Asian Pacific Journal of Cancer Prevention. 17 (6): 2741–4. PMID 27356683.
^ ^a ^b Wu J, Li L, Wu S, Xu B (August 2020). "CMTM family proteins 1-8: roles in cancer biological processes and potential clinical value". Cancer Biology & Medicine. 17 (3): 528–542. doi:10.20892/j.issn.2095-3941.2020.0032. PMC 7476098. PMID 32944388.
^ Ribas A, Wolchok JD (March 2018). "Cancer immunotherapy using checkpoint blockade". Science. 359 (6382): 1350–1355. Bibcode:2018Sci...359.1350R. doi:10.1126/science.aar4060. PMC 7391259. PMID 29567705.
^ "Entrez Gene: CKLF like MARVEL transmembrane domain-containing 6". Retrieved 2017-10-23.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000091317 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032434 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "CMTM6 CKLF like MARVEL transmembrane domain-containing 6 [Homo sapiens (Human)] - Gene - NCBI".

[pmid12782130-6] Han W, Ding P, Xu M, Wang L, Rui M, Shi S, Liu Y, Zheng Y, Chen Y, Yang T, Ma D (June 2003). "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation". Genomics. 81 (6): 609–17. doi:10.1016/s0888-7543(03)00095-8. PMID 12782130.

[pmid27356683-7] Lu J, Wu QQ, Zhou YB, Zhang KH, Pang BX, Li L, Sun N, Wang HS, Zhang S, Li WJ, Zheng W, Liu W (2016). "Cancer Research Advance in CKLF-like MARVEL Transmembrane Domain-Containing Member Family (Review)". Asian Pacific Journal of Cancer Prevention. 17 (6): 2741–4. PMID 27356683.

[pmid32944388-8] Wu J, Li L, Wu S, Xu B (August 2020). "CMTM family proteins 1-8: roles in cancer biological processes and potential clinical value". Cancer Biology & Medicine. 17 (3): 528–542. doi:10.20892/j.issn.2095-3941.2020.0032. PMC 7476098. PMID 32944388.

[pmid29567705-9] Ribas A, Wolchok JD (March 2018). "Cancer immunotherapy using checkpoint blockade". Science. 359 (6382): 1350–1355. Bibcode:2018Sci...359.1350R. doi:10.1126/science.aar4060. PMC 7391259. PMID 29567705.

[entrez-10] "Entrez Gene: CKLF like MARVEL transmembrane domain-containing 6". Retrieved 2017-10-23.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]