CKLF like MARVEL transmembrane domain containing 7

CMTM7
Identifiers
Aliases	CMTM7, CKLFSF7, CKLF like MARVEL transmembrane domain containing 7
External IDs	OMIM: 607890; MGI: 2447166; HomoloGene: 15882; GeneCards: CMTM7; OMA:CMTM7 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	32,483,067 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	114,610,924 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; pancreatic epithelial cell; ; spleen; ; mucosa of ileum; ; right lung; ; monocyte; ; right uterine tube; ; bone marrow; ; upper lobe of left lung;
	Top expressed in
	granulocyte; ; thymus; ; bone marrow; ; tibiofemoral joint; ; stroma of bone marrow; ; dermis; ; blastocyst; ; external carotid artery; ; yolk sac; ; ankle joint;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity;
Cellular component	membrane; extracellular space; integral component of membrane;
Biological process	chemotaxis; B-1a B cell differentiation; regulation of signaling receptor activity; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	112616
	102545
	ENSG00000153551
	ENSMUSG00000032436
	Q96FZ5
	Q9ESD6
	NM_138410; NM_181472
	NM_001252479; NM_133978
	NP_612419; NP_852137
	NP_001239408; NP_598739
	Wikidata
View/Edit Human	View/Edit Mouse

CKLF like MARVEL transmembrane domain-containing 7 (i.e. CMTM7), previously termed chemokine-like factor superfamily 7 (i.e. CKLFSF7), is a protein that in humans is encoded by the CMTM7 gene. This gene, which is located in band 22 on the short (i.e. "p") arm of chromosome 3, and the protein that it encodes belong to the CKLF-like MARVEL transmembrane domain-containing family. Through the process of alternative splicing, the CMTM7 gene encodes two isoforms, CMTM7-v1 and CMTM7-v2, with CMTM7-v1 being the main form expressed and studied. CMTM7 proteins are widely expressed in normal human tissues.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153551 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032436 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wu J, Li L, Wu S, Xu B (August 2020). "CMTM family proteins 1-8: roles in cancer biological processes and potential clinical value". Cancer Biology & Medicine. 17 (3): 528–542. doi:10.20892/j.issn.2095-3941.2020.0032. PMC 7476098. PMID 32944388.
^ "Entrez Gene: CKLF like MARVEL transmembrane domain-containing 7". Retrieved 2016-03-09.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153551 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032436 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid32944388-5] Wu J, Li L, Wu S, Xu B (August 2020). "CMTM family proteins 1-8: roles in cancer biological processes and potential clinical value". Cancer Biology & Medicine. 17 (3): 528–542. doi:10.20892/j.issn.2095-3941.2020.0032. PMC 7476098. PMID 32944388.

[entrez-6] "Entrez Gene: CKLF like MARVEL transmembrane domain-containing 7". Retrieved 2016-03-09.

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