CLCA1

CLCA1
Identifiers
Aliases	CLCA1, CACC, CACC1, CLCRG1, CaCC-1, GOB5, hhCaCC-1, chloride channel accessory 1
External IDs	OMIM: 603906; MGI: 1346342; HomoloGene: 984; GeneCards: CLCA1; OMA:CLCA1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	86,500,259 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	144,738,537 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; mucosa of sigmoid colon; ; jejunal mucosa; ; mucosa of transverse colon; ; rectum; ; duodenum; ; cecum; ; appendix; ; pancreatic ductal cell; ; epithelium of colon;
	Top expressed in
	left colon; ; intestinal villus; ; cervix; ; pyloric antrum; ; ileum; ; duodenum; ; mucous cell of stomach; ; crypt of lieberkuhn of small intestine; ; epithelium of small intestine; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; peptidase activity; hydrolase activity; chloride channel activity; metallopeptidase activity; metalloendopeptidase activity; intracellular calcium activated chloride channel activity;
Cellular component	extracellular region; integral component of membrane; integral component of plasma membrane; microvillus; zymogen granule membrane; membrane; plasma membrane; secretory granule; extracellular space;
Biological process	calcium ion transport; proteolysis; chloride transport; ion transport; ion transmembrane transport; cellular response to hypoxia; chloride transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	1179
	23844
	ENSG00000016490
	ENSMUSG00000028255
	A8K7I4
	Q9D7Z6
	NM_001285
	NM_017474
	NP_001276
	NP_059502
	Wikidata
View/Edit Human	View/Edit Mouse

Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene.^[5]^[6]

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.^[6] Protein structure prediction methods suggest the N-terminal region of CLCA1 protein is a zinc metalloprotease.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000016490 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028255 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gruber AD, Elble RC, Ji HL, Schreur KD, Fuller CM, Pauli BU (Jan 1999). "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca²⁺-activated Cl⁻ channel proteins". Genomics. 54 (2): 200–14. doi:10.1006/geno.1998.5562. PMID 9828122.
^ ^a ^b "Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1".
^ Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. S2CID 40041491.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000016490 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028255 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9828122-5] Gruber AD, Elble RC, Ji HL, Schreur KD, Fuller CM, Pauli BU (Jan 1999). "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca²⁺-activated Cl⁻ channel proteins". Genomics. 54 (2): 200–14. doi:10.1006/geno.1998.5562. PMID 9828122.

[entrez-6] "Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1".

[pmid16470849-7] Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. S2CID 40041491.

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