CLCN7

CLCN7
Identifiers
Aliases	CLCN7, CLC-7, CLC7, OPTA2, OPTB4, PPP1R63, chloride voltage-gated channel 7, HOD
External IDs	OMIM: 602727; MGI: 1347048; HomoloGene: 56546; GeneCards: CLCN7; OMA:CLCN7 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	1,475,084 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	25,381,078 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal cortex; ; right hemisphere of cerebellum; ; stromal cell of endometrium; ; granulocyte; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; spleen; ; anterior pituitary; ; right frontal lobe;
	Top expressed in
	superior surface of tongue; ; gallbladder; ; ganglion of vagus nerve; ; stroma of bone marrow; ; neural layer of retina; ; right kidney; ; decidua; ; entorhinal cortex; ; perirhinal cortex; ; ankle joint;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ion channel activity; antiporter activity; ATP binding; chloride channel activity; voltage-gated chloride channel activity; protein binding; chloride transmembrane transporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; lysosome; cytoplasmic vesicle; lysosomal membrane; membrane; nucleoplasm; intracellular membrane-bounded organelle;
Biological process	ion transmembrane transport; chloride transport; ion transport; regulation of anion transmembrane transport; response to pH; transmembrane transport; chloride transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
	1186
	26373
	ENSG00000103249
	ENSMUSG00000036636
	P51798
	O70496
	NM_001114331; NM_001287
	NM_011930; NM_001317404
	NP_001107803; NP_001278
	NP_001304333; NP_036060
	Wikidata
View/Edit Human	View/Edit Mouse

Chloride channel 7 alpha subunit also known as H⁺/Cl⁻ exchange transporter 7 is a protein that in humans is encoded by the CLCN7 gene.^[5] In melanocytic cells this gene is regulated by the Microphthalmia-associated transcription factor.^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103249 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036636 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CLCN7 chloride channel 7".
^ Meadows NA, Sharma SM, Faulkner GJ, Ostrowski MC, Hume DA, Cassady AI (2007). "The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor". J. Biol. Chem. 282 (3): 1891–904. doi:10.1074/jbc.M608572200. PMID 17105730.
^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103249 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036636 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CLCN7 chloride channel 7".

[pmid17105730-6] Meadows NA, Sharma SM, Faulkner GJ, Ostrowski MC, Hume DA, Cassady AI (2007). "The expression of Clcn7 and Ostm1 in osteoclasts is coregulated by microphthalmia transcription factor". J. Biol. Chem. 282 (3): 1891–904. doi:10.1074/jbc.M608572200. PMID 17105730.

[pmid19067971-7] Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

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