CLNS1A

CLNS1A
Identifiers
Aliases	CLNS1A, CLCI, CLNS1B, ICln, chloride nucleotide-sensitive channel 1A
External IDs	OMIM: 602158; MGI: 109638; HomoloGene: 990; GeneCards: CLNS1A; OMA:CLNS1A - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	77,637,794 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	97,370,003 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; Achilles tendon; ; ganglionic eminence; ; body of pancreas; ; right adrenal gland; ; right adrenal cortex; ; left ovary; ; C1 segment; ; left adrenal gland; ; monocyte;
	Top expressed in
	motor neuron; ; primitive streak; ; medial ganglionic eminence; ; condyle; ; fossa; ; vestibular membrane of cochlear duct; ; hair follicle; ; Rostral migratory stream; ; renal corpuscle; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein heterodimerization activity; protein binding; RNA binding;
Cellular component	plasma membrane; cytoskeleton; nucleoplasm; nucleus; methylosome; pICln-Sm protein complex; cytosol; cytoplasm;
Biological process	cell volume homeostasis; chloride transport; spliceosomal snRNP assembly;
	Sources:Amigo / QuickGO
Orthologs
	1207
	12729
	ENSG00000074201
	ENSMUSG00000025439
	P54105
	Q61189; Q923F1
	NM_001311202; NM_001293; NM_001311199; NM_001311200; NM_001311201
	NM_023671
	NP_001284; NP_001298128; NP_001298129; NP_001298130; NP_001298131
	NP_076160
	Wikidata
View/Edit Human	View/Edit Mouse

Methylosome subunit pICln is a protein that in humans is encoded by the CLNS1A gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000074201 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025439 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Anguita J, Chalfant ML, Civan MM, Coca-Prados M (Apr 1995). "Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, pICln, from ocular ciliary epithelium". Biochem Biophys Res Commun. 208 (1): 89–95. doi:10.1006/bbrc.1995.1309. PMID 7887970.
^ Nagl UO, Erdel M, Schmarda A, Seri M, Pinggera GM, Gschwentner M, Duba C, Galietta LJ, Deetjen P, Utermann G, Paulmichl M (Mar 1997). "Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel ICln". Genomics. 38 (3): 438–41. doi:10.1006/geno.1996.0651. PMID 8975725.
^ "Entrez Gene: CLNS1A chloride channel, nucleotide-sensitive, 1A".