COP9 signalosome complex subunit 3

COPS3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4D10, 4D18, 4WSN
Identifiers
Aliases	COPS3, CSN3, SGN3, COP9 signalosome subunit 3
External IDs	OMIM: 604665; MGI: 1349409; HomoloGene: 2710; GeneCards: COPS3; OMA:COPS3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	17,281,273 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	59,839,838 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; gonad; ; muscle of thigh; ; ganglionic eminence; ; right testis; ; left testis; ; skeletal muscle tissue; ; Skeletal muscle tissue of rectus abdominis; ; vastus lateralis muscle; ; muscle of arm;
	Top expressed in
	spermatocyte; ; facial motor nucleus; ; medial ganglionic eminence; ; spermatid; ; abdominal wall; ; mandibular prominence; ; maxillary prominence; ; intercostal muscle; ; primitive streak; ; endocardial cushion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	COP9 signalosome; nucleus; nucleoplasm; cytoplasm; cytosol;
Biological process	transcription-coupled nucleotide-excision repair; in utero embryonic development; ubiquitin-dependent protein catabolic process; nucleotide-excision repair, DNA damage recognition; signal transduction; response to light stimulus; protein deneddylation; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	8533
	26572
	ENSG00000141030
	ENSMUSG00000019373
	Q9UNS2
	O88543
NM_001199125; NM_003653; NM_001316354; NM_001316355; NM_001316356;
	NM_001316357; NM_001316358
	NM_011991
NP_001186054; NP_001303283; NP_001303284; NP_001303285; NP_001303286;
	NP_001303287; NP_003644
	NP_036121
	Wikidata
View/Edit Human	View/Edit Mouse

COP9 signalosome complex subunit 3 is a protein that in humans is encoded by the COPS3 gene.^[5]^[6]^[7] It encodes a subunit of the COP9 signalosome.

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I-kappa-B-alpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141030 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019373 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (Apr 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. doi:10.1096/fasebj.12.6.469. PMID 9535219. S2CID 25424324.
^ Potocki L, Chen KS, Lupski JR (Jun 1999). "Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2". Genomics. 57 (1): 180–2. doi:10.1006/geno.1998.5748. PMID 10191102.
^ ^a ^b "Entrez Gene: COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141030 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019373 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9535219-5] Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W (Apr 1998). "A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits". FASEB J. 12 (6): 469–78. doi:10.1096/fasebj.12.6.469. PMID 9535219. S2CID 25424324.

[pmid10191102-6] Potocki L, Chen KS, Lupski JR (Jun 1999). "Subunit 3 of the COP9 signal transduction complex is conserved from plants to humans and maps within the smith-magenis syndrome critical region in 17p11.2". Genomics. 57 (1): 180–2. doi:10.1006/geno.1998.5748. PMID 10191102.

[entrez-7] "Entrez Gene: COPS3 COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)".

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