CPSF1

CPSF1
Identifiers
Aliases	CPSF1, CPSF160, HSU37012, P/cl.18, cleavage and polyadenylation specific factor 1
External IDs	OMIM: 606027; MGI: 2679722; HomoloGene: 40865; GeneCards: CPSF1; OMA:CPSF1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	144,409,349 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	76,491,791 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; right hemisphere of cerebellum; ; right uterine tube; ; granulocyte; ; pituitary gland; ; anterior pituitary; ; duodenum; ; mucosa of transverse colon; ; spleen;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; hair follicle; ; primitive streak; ; vestibular membrane of cochlear duct; ; endothelial cell of lymphatic vessel; ; epiblast; ; neural layer of retina; ; ventricular zone; ; adrenal gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; enzyme binding; protein binding; mRNA 3'-UTR AU-rich region binding; RNA binding;
Cellular component	mRNA cleavage and polyadenylation specificity factor complex; nucleus; nucleoplasm;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA polyadenylation; mRNA processing; mRNA cleavage; mRNA 3'-end processing; mRNA export from nucleus; pre-mRNA cleavage required for polyadenylation; tRNA splicing, via endonucleolytic cleavage and ligation;
	Sources:Amigo / QuickGO
Orthologs
	29894
	94230
	ENSG00000071894
	ENSMUSG00000034022
	Q10570
	Q9EPU4
	NM_013291
	NM_001164173; NM_053193; NM_001361485
	NP_037423
	NP_001157645; NP_444423; NP_001348414
	Wikidata
View/Edit Human	View/Edit Mouse

Cleavage and polyadenylation specificity factor subunit 1 is a protein that in humans is encoded by the CPSF1 gene.^[5]^[6]^[7]

In most cases eukaryotic pre-messenger(m)RNA 3 prime ends are processed in two coordinated steps. First there is a site-specific cleavage by an endonuclease and then the addition of a poly(A) tail at the 3 prime end of the 5 prime cleavage product. Cleavage requires four multisubunit complexes, namely cleavage and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), cleavage factors Im and IIm (CFIm and CFIIm), along with a single subunit poly(A)polymerase (PAP). CPSF1 is the largest component of the CPSF complex composed of CPSF1, CPSF2, CPSF3, CPSF4, FIP1L1, Symplekin and WDR33 and located in the nucleus.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000071894 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034022 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jenny A, Keller W (Sep 1995). "Cloning of cDNAs encoding the 160 kDa subunit of the bovine cleavage and polyadenylation specificity factor". Nucleic Acids Res. 23 (14): 2629–35. doi:10.1093/nar/23.14.2629. PMC 307085. PMID 7651824.
^ Murthy KG, Manley JL (Dec 1995). "The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation". Genes Dev. 9 (21): 2672–83. doi:10.1101/gad.9.21.2672. PMID 7590244.
^ "Entrez Gene: CPSF1 cleavage and polyadenylation specific factor 1, 160kDa".
^ Shi Y, Di Giammartino DC, Taylor D, Sarkeshik A, Rice WJ, Yates JR, Frank J, Manley JL (February 2009). "Molecular architecture of the human pre-mRNA 3' processing complex". Mol. Cell. 33 (3): 365–76. doi:10.1016/j.molcel.2008.12.028. PMC 2946185. PMID 19217410.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000071894 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034022 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7651824-5] Jenny A, Keller W (Sep 1995). "Cloning of cDNAs encoding the 160 kDa subunit of the bovine cleavage and polyadenylation specificity factor". Nucleic Acids Res. 23 (14): 2629–35. doi:10.1093/nar/23.14.2629. PMC 307085. PMID 7651824.

[pmid7590244-6] Murthy KG, Manley JL (Dec 1995). "The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation". Genes Dev. 9 (21): 2672–83. doi:10.1101/gad.9.21.2672. PMID 7590244.

[entrez-7] "Entrez Gene: CPSF1 cleavage and polyadenylation specific factor 1, 160kDa".

[pmid19217410-8] Shi Y, Di Giammartino DC, Taylor D, Sarkeshik A, Rice WJ, Yates JR, Frank J, Manley JL (February 2009). "Molecular architecture of the human pre-mRNA 3' processing complex". Mol. Cell. 33 (3): 365–76. doi:10.1016/j.molcel.2008.12.028. PMC 2946185. PMID 19217410.

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