CRABP1

CRABP1
Identifiers
Aliases	CRABP1, CRABP, CRABP-I, CRABPI, RBP5, cellular retinoic acid binding protein 1
External IDs	OMIM: 180230; MGI: 88490; HomoloGene: 3222; GeneCards: CRABP1; OMA:CRABP1 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	78,348,225 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	54,680,394 bp
RNA expression pattern
	Top expressed in
	left lobe of thyroid gland; ; right lobe of thyroid gland; ; caudate nucleus; ; nucleus accumbens; ; middle frontal gyrus; ; gonad; ; superior vestibular nucleus; ; spleen; ; putamen; ; trigeminal ganglion;
	Top expressed in
	otic placode; ; otic vesicle; ; maxillary prominence; ; external carotid artery; ; somite; ; desmocranium; ; mandibular prominence; ; abdominal wall; ; genital tubercle; ; internal carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	retinol binding; retinoic acid binding; protein binding; retinoid binding; retinal binding; lipid binding;
Cellular component	cytoplasm; cytosol;
Biological process	multicellular organism development; retinoic acid catabolic process; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	1381
	12903
	ENSG00000166426
	ENSMUSG00000032291
	P29762
	P62965
	NM_004378
	NM_001284507; NM_013496
	NP_004369
	NP_001271436; NP_038524
	Wikidata
View/Edit Human	View/Edit Mouse

Cellular retinoic acid-binding protein 1 is a protein that in humans is encoded by the CRABP1 gene.^[5]^[6]

CRABP1 is assumed to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid. CRABP1 is constitutively expressed and is believed to have different functions in the cell than the related CRABP2.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166426 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032291 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Flagiello D, Apiou F, Gibaud A, Poupon MF, Dutrillaux B, Malfoy B (Jun 1997). "Assignment of the genes for cellular retinoic acid binding protein 1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and 1q21.3, respectively, by in situ hybridization". Cytogenetics and Cell Genetics. 76 (1–2): 17–8. doi:10.1159/000134502. PMID 9154115.
^ ^a ^b "Entrez Gene: CRABP1 cellular retinoic acid binding protein 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166426 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032291 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9154115-5] Flagiello D, Apiou F, Gibaud A, Poupon MF, Dutrillaux B, Malfoy B (Jun 1997). "Assignment of the genes for cellular retinoic acid binding protein 1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and 1q21.3, respectively, by in situ hybridization". Cytogenetics and Cell Genetics. 76 (1–2): 17–8. doi:10.1159/000134502. PMID 9154115.

[entrez-6] "Entrez Gene: CRABP1 cellular retinoic acid binding protein 1".

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