CREB-binding protein

CREBBP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JSP, 1LIQ, 1RDT, 1WO3, 1WO4, 1WO5, 1WO6, 1WO7, 2D82, 2KJE, 2KWF, 2L84, 2L85, 2LXS, 2LXT, 2RNY, 3DWY, 3P1C, 3P1D, 3P1E, 3P1F, 3SVH, 4A9K, 4N3W, 4N4F, 4NR4, 4NR5, 4NR6, 4NR7, 4NYV, 4NYW, 4NYX, 4OUF, 4TQN, 4TS8, 4WHU, 5JEM, 5I8B, 5I89, 5I86, 4YK0, 5CGP, 5I8G, 2N1A, 5I83, 1ZOQ, 5DBM
Identifiers
Aliases	CREBBP, AW558298, CBP, CBP/p300, KAT3A, p300/CBP, RSTS, CREB binding protein, RSTS1, MKHK1
External IDs	OMIM: 600140; MGI: 1098280; HomoloGene: 68393; GeneCards: CREBBP; OMA:CREBBP - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 3,725,054 bp[1] End 3,880,713 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A1|16 2.4 cM Start 3,899,192 bp[2] End 4,031,861 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve tibia amniotic fluid germinal epithelium Achilles tendon endothelial cell bone marrow cells skin of hip caput epididymis testicle Top expressed in Rostral migratory stream ascending aorta aortic valve Gonadal ridge Ileal epithelium cumulus cell secondary oocyte zygote primary oocyte ciliary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity transcription coactivator activity MRF binding zinc ion binding p53 binding transcription factor binding chromatin binding cis-regulatory region sequence-specific DNA binding transcription coregulator activity signal transducer activity metal ion binding histone acetyltransferase activity damaged DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding acetyltransferase activity acyltransferase activity peptide N-acetyltransferase activity DNA-binding transcription factor activity transcription corepressor activity Cellular component cytoplasm nucleoplasm histone acetyltransferase complex nucleus nuclear body Biological process Notch signaling pathway response to hypoxia regulation of transcription, DNA-templated rhythmic process cellular response to UV embryonic digit morphogenesis N-terminal peptidyl-lysine acetylation stimulatory C-type lectin receptor signaling pathway negative regulation of transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of smoothened signaling pathway histone acetylation regulation of transcription from RNA polymerase II promoter in response to hypoxia regulation of cellular response to heat transcription initiation from RNA polymerase II promoter viral process positive regulation of type I interferon production signal transduction protein acetylation homeostatic process beta-catenin-TCF complex assembly regulation of apoptotic process positive regulation of transcription by RNA polymerase II regulation of lipid metabolic process protein destabilization regulation of myeloid cell differentiation positive regulation of transcription of Notch receptor target positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of Notch signaling pathway protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1387 12914 Ensembl ENSG00000005339 ENSMUSG00000022521 UniProt Q92793 P45481 RefSeq (mRNA) NM_001079846 NM_004380 NM_001025432 RefSeq (protein) NP_001073315 NP_004371 n/a Location (UCSC) Chr 16: 3.73 – 3.88 Mb Chr 16: 3.9 – 4.03 Mb PubMed search [3] [4]
Wikidata
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CREB-binding protein, also known as CREBBP or CBP or KAT3A, (where CREB is cAMP response element-binding protein) is a coactivator encoded by the CREBBP gene in humans, located on chromosome 16p13.3.^[5][6] CBP has intrinsic acetyltransferase functions; it is able to add acetyl groups to both transcription factors as well as histone lysines, the latter of which has been shown to alter chromatin structure making genes more accessible for transcription.^{[7][8][9][10]} This relatively unique acetyltransferase activity is also seen in another transcription enzyme, EP300 (p300). Together, they are known as the p300-CBP coactivator family and are known to associate with more than 16,000 genes in humans; however, while these proteins share many structural features, emerging evidence suggests that these two co-activators may promote transcription of genes with different biological functions.^[7][11][12]

For example, CBP alone has been implicated in a wide variety of pathophysiologies including colorectal cancer as well as head and neck squamous cell carcinoma. In these diseases, association of CBP with β-catenin has been shown to promote cancer cell proliferation and disease aggressiveness, whereas p300/ β-catenin leads to cell differentiation and/ or apoptosis.^[11][13] CBP has also been shown to help modulate liver function via maintenance of energy homeostasis in response to changes in cell nutrition conditions by regulating the activity of transcription factors and genes responsible for lipogenesis and gluconeogenesis.^[6] CBP is also implicated in the etiologies of several other diseases including hematologic malignancies and other solid tumors, diabetes, schizophrenia, Alzheimer's disease, depression, and many other neurological conditions.^{[14][15][16][17][18]}