CRYM

CRYM
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I99
Identifiers
Aliases	CRYM, DFNA40, THBP, crystallin mu
External IDs	OMIM: 123740; MGI: 102675; HomoloGene: 1424; GeneCards: CRYM; OMA:CRYM - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p12.2 Start 21,238,874 bp[1] End 21,303,083 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 F2|7 64.47 cM Start 119,785,603 bp[2] End 119,801,334 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis frontal pole paraflocculus of cerebellum right hemisphere of cerebellum Brodmann area 10 orbitofrontal cortex apex of heart nucleus accumbens Brodmann area 9 right frontal lobe Top expressed in dentate gyrus of hippocampal formation granule cell hippocampus proper olfactory tubercle nucleus accumbens subiculum lip dorsal striatum Region I of hippocampus proper superior frontal gyrus CA3 field More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity hormone binding protein binding protein homodimerization activity transcription corepressor activity NADP binding thyroid hormone binding thiomorpholine-carboxylate dehydrogenase activity oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Cellular component cytoplasm extracellular exosome mitochondrion nucleus peroxisomal matrix cytosol Biological process thyroid hormone transport negative regulation of transcription by RNA polymerase II hearing lysine catabolic process thyroid hormone metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1428 12971 Ensembl ENSG00000103316 ENSMUSG00000030905 UniProt Q14894 O54983 RefSeq (mRNA) NM_001014444 NM_001888 NM_001376256 NM_016669 RefSeq (protein) NP_001879 NP_001363185 NP_057878 Location (UCSC) Chr 16: 21.24 – 21.3 Mb Chr 7: 119.79 – 119.8 Mb PubMed search [3] [4]
Wikidata
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Mu-crystallin homolog also known as NADP-regulated thyroid-hormone-binding protein (THBP) is a protein that in humans is encoded by the CRYM gene. Multiple alternatively spliced transcript variants have been found for this gene.^[5][6]