CSNK1E

CSNK1E
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4HNI, 4HOK
Identifiers
Aliases	CSNK1E, CKIepsilon, HCKIE, Casein kinase 1 isoform epsilon, casein kinase 1 epsilon, CKIe
External IDs	OMIM: 600863; MGI: 1351660; HomoloGene: 121695; GeneCards: CSNK1E; OMA:CSNK1E - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	38,318,084 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	79,339,767 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; left ovary; ; ventricular zone; ; right uterine tube; ; canal of the cervix; ; body of uterus; ; right ovary; ; stromal cell of endometrium; ; anterior pituitary; ; skin of leg;
	Top expressed in
	zygote; ; secondary oocyte; ; ganglionic eminence; ; lip; ; genital tubercle; ; ventricular zone; ; medial ganglionic eminence; ; Rostral migratory stream; ; granulocyte; ; tail of embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; RNA binding;
Cellular component	cytoplasm; cytosol; nucleus; nucleoplasm; growth cone; neuron projection; neuronal cell body;
Biological process	phosphorylation; rhythmic process; Wnt signaling pathway; negative regulation of protein binding; protein phosphorylation; G2/M transition of mitotic cell cycle; peptidyl-serine phosphorylation; DNA repair; signal transduction; endocytosis; regulation of cell shape; rRNA processing; ciliary basal body-plasma membrane docking; positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; circadian regulation of gene expression; regulation of circadian rhythm; positive regulation of non-canonical Wnt signaling pathway; regulation of G2/M transition of mitotic cell cycle; circadian behavior; positive regulation of amyloid-beta formation; cellular response to nerve growth factor stimulus; peptidyl-threonine phosphorylation; canonical Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1454
	27373
	ENSG00000213923
	ENSMUSG00000022433
	P49674
	Q9JMK2
	NM_001894; NM_152221
	NM_013767; NM_001289898; NM_001289899; NM_001359862; NM_001359863
	NP_001885; NP_689407
	NP_001276827; NP_001276828; NP_038795; NP_001346791; NP_001346792
	Wikidata
View/Edit Human	View/Edit Mouse

Casein kinase I isoform epsilon is an enzyme that in humans is encoded by the CSNK1E gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000213923 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022433 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fish KJ, Cegielska A, Getman ME, Landes GM, Virshup DM (Jun 1995). "Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family". The Journal of Biological Chemistry. 270 (25): 14875–83. doi:10.1074/jbc.270.25.14875. PMID 7797465.
^ Sakanaka C, Leong P, Xu L, Harrison SD, Williams LT (Oct 1999). "Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function". Proceedings of the National Academy of Sciences of the United States of America. 96 (22): 12548–52. doi:10.1073/pnas.96.22.12548. PMC 22983. PMID 10535959.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213923 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022433 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7797465-5] Fish KJ, Cegielska A, Getman ME, Landes GM, Virshup DM (Jun 1995). "Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family". The Journal of Biological Chemistry. 270 (25): 14875–83. doi:10.1074/jbc.270.25.14875. PMID 7797465.

[pmid10535959-6] Sakanaka C, Leong P, Xu L, Harrison SD, Williams LT (Oct 1999). "Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function". Proceedings of the National Academy of Sciences of the United States of America. 96 (22): 12548–52. doi:10.1073/pnas.96.22.12548. PMC 22983. PMID 10535959.

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