CTBP2

CTBP2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2OME, 4LCJ
Identifiers
Aliases	CTBP2, C-terminal binding protein 2
External IDs	OMIM: 602619; MGI: 1201686; HomoloGene: 75187; GeneCards: CTBP2; OMA:CTBP2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	125,161,170 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	133,124,354 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; buccal mucosa cell; ; mucosa of paranasal sinus; ; pylorus; ; cardia; ; retinal pigment epithelium; ; renal medulla; ; dorsal motor nucleus of vagus nerve; ; nasal epithelium; ; caput epididymis;
	Top expressed in
	saccule; ; otic placode; ; otic vesicle; ; migratory enteric neural crest cell; ; abdominal wall; ; retina; ; epiblast; ; Gonadal ridge; ; neural layer of retina; ; vas deferens;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; NAD binding; protein binding; oxidoreductase activity; hydroxypyruvate reductase activity; protein kinase binding; glyoxylate reductase (NADP+) activity; protein homodimerization activity; protein-containing complex binding; transcription corepressor activity; chromatin binding; transcription coactivator activity; retinoic acid receptor binding; structural constituent of presynaptic active zone;
Cellular component	synapse; cell junction; nucleus; cytosol; transcription repressor complex; ribbon synapse; presynaptic active zone cytoplasmic component; glutamatergic synapse; GABA-ergic synapse; presynaptic cytosol; photoreceptor ribbon synapse;
Biological process	cell differentiation; regulation of transcription, DNA-templated; viral genome replication; transcription, DNA-templated; metabolism; viral process; negative regulation of cell population proliferation; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; positive regulation of retinoic acid receptor signaling pathway; white fat cell differentiation; positive regulation of chromatin binding; cellular response to leukemia inhibitory factor; synaptic vesicle docking; maintenance of presynaptic active zone structure;
	Sources:Amigo / QuickGO
Orthologs
	1488
	13017
	ENSG00000175029
	ENSMUSG00000030970
	P56545
	P56546
NM_001083914; NM_001290214; NM_001290215; NM_001329; NM_022802;
	NM_001321012; NM_001321013; NM_001321014; NM_001363508
	NM_001170744; NM_009980; NM_001347623
NP_001077383; NP_001277143; NP_001277144; NP_001307941; NP_001307942;
	NP_001307943; NP_001320; NP_073713; NP_001350437
	NP_001164215; NP_001334552; NP_034110
	Wikidata
View/Edit Human	View/Edit Mouse

C-terminal-binding protein 2 also known as CtBP2 is a protein that in humans is encoded by the CTBP2 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175029 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030970 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Turner J, Crossley M (September 1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMC 1170841. PMID 9724649.
^ Chinnadurai G (February 2002). "CtBP, an unconventional transcriptional corepressor in development and oncogenesis". Mol. Cell. 9 (2): 213–24. doi:10.1016/S1097-2765(02)00443-4. PMID 11864595.
^ "Entrez Gene: CTBP2 C-terminal binding protein 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000175029 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030970 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9724649-5] Turner J, Crossley M (September 1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMC 1170841. PMID 9724649.

[pmid11864595-6] Chinnadurai G (February 2002). "CtBP, an unconventional transcriptional corepressor in development and oncogenesis". Mol. Cell. 9 (2): 213–24. doi:10.1016/S1097-2765(02)00443-4. PMID 11864595.

[entrez-7] "Entrez Gene: CTBP2 C-terminal binding protein 2".

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