CTCF

CTCF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X6H, 2CT1
Identifiers
Aliases	CTCF, MRD21, CCCTC-binding factor, FAP108, CFAP108
External IDs	OMIM: 604167; MGI: 109447; HomoloGene: 4786; GeneCards: CTCF; OMA:CTCF - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	67,639,177 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	105,682,922 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; thymus; ; cerebellar vermis; ; paraflocculus of cerebellum; ; lymph node; ; trabecular bone; ; Skeletal muscle tissue of rectus abdominis; ; bone marrow; ; skin of thigh;
	Top expressed in
	Rostral migratory stream; ; thymus; ; neural layer of retina; ; tail of embryo; ; saccule; ; genital tubercle; ; otic placode; ; ventricular zone; ; otic vesicle; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription corepressor activity; DNA-binding transcription factor activity; zinc ion binding; metal ion binding; chromatin insulator sequence binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; nucleic acid binding; DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding;
Cellular component	nucleoplasm; chromosome; nucleolus; chromosome, centromeric region; condensed chromosome; nucleus;
Biological process	regulation of transcription, DNA-templated; regulation of gene expression, epigenetic; regulation of centromeric sister chromatid cohesion; chromosome segregation; transcription, DNA-templated; positive regulation of transcription, DNA-templated; negative regulation of transcription, DNA-templated; protein localization to chromosome, centromeric region; negative regulation of cell population proliferation; chromatin organization; negative regulation of transcription by RNA polymerase II; positive regulation of gene expression; DNA methylation; regulation of gene expression by genetic imprinting; maintenance of DNA methylation; negative regulation of gene expression; regulation of histone methylation; regulation of histone acetylation; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	10664
	13018
	ENSG00000102974
	ENSMUSG00000005698
	P49711
	Q61164
	NM_001191022; NM_006565; NM_001363916
	NM_181322; NM_001358924
	NP_001177951; NP_006556; NP_001350845
NP_851839; NP_001345853; NP_001390652; NP_001390653; NP_001390654;
	NP_001390655; NP_001390656; NP_001390657; NP_001390658; NP_001390659; NP_001390660; NP_001390661
	Wikidata
View/Edit Human	View/Edit Mouse

Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene.^[5]^[6] CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination^[7] and regulation of chromatin architecture.^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102974 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005698 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Filippova GN, Fagerlie S, Klenova EM, Myers C, Dehner Y, Goodwin G, Neiman PE, Collins SJ, Lobanenkov VV (June 1996). "An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes". Mol. Cell. Biol. 16 (6): 2802–13. doi:10.1128/mcb.16.6.2802. PMC 231272. PMID 8649389.
^ Rubio ED, Reiss DJ, Welcsh PL, Disteche CM, Filippova GN, Baliga NS, Aebersold R, Ranish JA, Krumm A (June 2008). "CTCF physically links cohesin to chromatin". Proc. Natl. Acad. Sci. U.S.A. 105 (24): 8309–14. Bibcode:2008PNAS..105.8309R. doi:10.1073/pnas.0801273105. PMC 2448833. PMID 18550811.
^ Chaumeil J, Skok JA (April 2012). "The role of CTCF in regulating V(D)J recombination". Curr. Opin. Immunol. 24 (2): 153–9. doi:10.1016/j.coi.2012.01.003. PMC 3444155. PMID 22424610.
^ Phillips JE; Corces VG (June 2009). "CTCF: master weaver of the genome". Cell. 137 (7): 1194–211. doi:10.1016/j.cell.2009.06.001. PMC 3040116. PMID 19563753.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102974 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005698 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8649389-5] Filippova GN, Fagerlie S, Klenova EM, Myers C, Dehner Y, Goodwin G, Neiman PE, Collins SJ, Lobanenkov VV (June 1996). "An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes". Mol. Cell. Biol. 16 (6): 2802–13. doi:10.1128/mcb.16.6.2802. PMC 231272. PMID 8649389.

[pmid18550811-6] Rubio ED, Reiss DJ, Welcsh PL, Disteche CM, Filippova GN, Baliga NS, Aebersold R, Ranish JA, Krumm A (June 2008). "CTCF physically links cohesin to chromatin". Proc. Natl. Acad. Sci. U.S.A. 105 (24): 8309–14. Bibcode:2008PNAS..105.8309R. doi:10.1073/pnas.0801273105. PMC 2448833. PMID 18550811.

[pmid22424610-7] Chaumeil J, Skok JA (April 2012). "The role of CTCF in regulating V(D)J recombination". Curr. Opin. Immunol. 24 (2): 153–9. doi:10.1016/j.coi.2012.01.003. PMC 3444155. PMID 22424610.

[Phillips_Corces_2009-8] Phillips JE; Corces VG (June 2009). "CTCF: master weaver of the genome". Cell. 137 (7): 1194–211. doi:10.1016/j.cell.2009.06.001. PMC 3040116. PMID 19563753.

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