CUL1

CUL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LDJ, 1LDK, 1U6G, 3RTR, 3TDU, 3TDZ, 4F52, 4P5O
Identifiers
Aliases	CUL1, cullin 1
External IDs	OMIM: 603134; MGI: 1349658; HomoloGene: 2663; GeneCards: CUL1; OMA:CUL1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q36.1 Start 148,697,914 bp[1] End 148,801,110 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B2.3 Start 47,430,332 bp[2] End 47,503,073 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte left testis right testis ganglionic eminence sperm gastrocnemius muscle Achilles tendon biceps brachii ventricular zone Skeletal muscle tissue of biceps brachii Top expressed in secondary oocyte zygote tail of embryo genital tubercle primary oocyte ventricular zone medullary collecting duct spermatocyte renal corpuscle neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase binding ubiquitin protein ligase activity ubiquitin-protein transferase activity Cellular component Parkin-FBXW7-Cul1 ubiquitin ligase complex nucleoplasm cytosol cullin-RING ubiquitin ligase complex SCF ubiquitin ligase complex Biological process intrinsic apoptotic signaling pathway viral process G2/M transition of mitotic cell cycle stress-activated MAPK cascade ubiquitin-dependent protein catabolic process protein monoubiquitination cell population proliferation negative regulation of cell population proliferation animal organ morphogenesis apoptotic process NIK/NF-kappaB signaling protein ubiquitination protein polyubiquitination Wnt signaling pathway SCF complex assembly negative regulation of G2/M transition of mitotic cell cycle cellular iron ion homeostasis post-translational protein modification G1/S transition of mitotic cell cycle interleukin-1-mediated signaling pathway SCF-dependent proteasomal ubiquitin-dependent protein catabolic process regulation of mitotic cell cycle phase transition proteasome-mediated ubiquitin-dependent protein catabolic process stimulatory C-type lectin receptor signaling pathway Fc-epsilon receptor signaling pathway T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8454 26965 Ensembl ENSG00000055130 ENSMUSG00000029686 UniProt Q13616 Q9WTX6 RefSeq (mRNA) NM_003592 NM_012042 NM_001355550 NM_001355551 RefSeq (protein) NP_003583 NP_036172 NP_001342479 NP_001342480 Location (UCSC) Chr 7: 148.7 – 148.8 Mb Chr 6: 47.43 – 47.5 Mb PubMed search [3] [4]
Wikidata
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Cullin 1, also known as CUL1, is a human protein and gene from cullin family. This protein plays an important role in protein degradation and protein ubiquitination.

This is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, it serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.

This protein is a part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. It also interacts with RNF7. Part of a complex with TIP120A/CAND1 and RBX1. The unneddylated form interacts with TIP120A/CAND1 and the interaction negatively regulates the association with SKP1 in the SCF complex. Interacts with COPS2.

It is expressed in lung fibroblasts.

The protein is neddylated, which enhances the ubiquitination activity of SCF. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.