CUL2

CUL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WQO
Identifiers
Aliases	CUL2, cullin 2
External IDs	OMIM: 603135; MGI: 1918995; HomoloGene: 2662; GeneCards: CUL2; OMA:CUL2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	35,127,006 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	3,436,377 bp
RNA expression pattern
	Top expressed in
	sperm; ; muscle of thigh; ; gastrocnemius muscle; ; gonad; ; Achilles tendon; ; ventricular zone; ; stromal cell of endometrium; ; islet of Langerhans; ; ganglionic eminence; ; biceps brachii;
	Top expressed in
	superior cervical ganglion; ; epiblast; ; abdominal wall; ; facial motor nucleus; ; arcuate nucleus; ; ventromedial nucleus; ; paraventricular nucleus of hypothalamus; ; lateral hypothalamus; ; sternocleidomastoid muscle; ; neural tube;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin protein ligase activity; ubiquitin protein ligase binding; protein-containing complex binding;
Cellular component	cullin-RING ubiquitin ligase complex; cytosol; nucleolus; VCB complex; nucleoplasm; Cul2-RING ubiquitin ligase complex; SCF ubiquitin ligase complex;
Biological process	intrinsic apoptotic signaling pathway; viral process; protein catabolic process; regulation of transcription from RNA polymerase II promoter in response to hypoxia; negative regulation of cell population proliferation; ubiquitin-dependent protein catabolic process; post-translational protein modification; G1/S transition of mitotic cell cycle; protein ubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8453
	71745
	ENSG00000108094
	ENSMUSG00000024231
	Q13617
	Q9D4H8
NM_001198777; NM_001198778; NM_001198779; NM_003591; NM_001324375;
	NM_001324376
	NM_029402; NM_001360829
NP_001185706; NP_001185707; NP_001185708; NP_001311304; NP_001311305;
	NP_003582
	NP_083678; NP_001347758
	Wikidata
View/Edit Human	View/Edit Mouse

Cullin-2 is a protein that in humans is encoded by the CUL2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108094 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024231 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM (Aug 1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family". Cell. 85 (6): 829–39. doi:10.1016/S0092-8674(00)81267-2. PMID 8681378. S2CID 15805562.
^ "Entrez Gene: CUL2 cullin 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108094 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024231 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8681378-5] Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM (Aug 1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family". Cell. 85 (6): 829–39. doi:10.1016/S0092-8674(00)81267-2. PMID 8681378. S2CID 15805562.

[entrez-6] "Entrez Gene: CUL2 cullin 2".

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