CUL3

CUL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MYL, 2MYM, 4AP2, 4APF, 4EOZ, 4HXI
Identifiers
Aliases	CUL3, CUL-3, PHA2E, cullin 3, NEDAUS
External IDs	OMIM: 603136; MGI: 1347360; HomoloGene: 2661; GeneCards: CUL3; OMA:CUL3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q36.2 Start 224,470,150 bp[1] End 224,585,397 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C5 Start 80,242,640 bp[2] End 80,318,197 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis amniotic fluid epithelium of nasopharynx glutes Achilles tendon parotid gland oral cavity palpebral conjunctiva Top expressed in spermatid spermatocyte seminiferous tubule triceps brachii muscle tail of embryo extensor digitorum longus muscle muscle of thigh quadriceps femoris muscle gastrocnemius muscle sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function POZ domain binding protein homodimerization activity ubiquitin protein ligase activity ubiquitin-protein transferase activity protein binding protein heterodimerization activity ubiquitin protein ligase binding cyclin binding Notch binding Cellular component cytoplasm cullin-RING ubiquitin ligase complex cytosol Golgi apparatus membrane Cul3-RING ubiquitin ligase complex nucleoplasm polar microtubule extracellular exosome nucleus Golgi membrane cilium SCF ubiquitin ligase complex motile cilium sperm flagellum cell projection Biological process embryonic cleavage regulation of transcription by RNA polymerase II G1 phase negative regulation of Rho protein signal transduction protein polyubiquitination in utero embryonic development negative regulation of transcription by RNA polymerase II Wnt signaling pathway protein monoubiquitination stress fiber assembly MAPK cascade positive regulation of cytokinesis intrinsic apoptotic signaling pathway endoplasmic reticulum to Golgi vesicle-mediated transport positive regulation of mitotic metaphase/anaphase transition COPII vesicle coating fibroblast apoptotic process cell projection organization gastrulation stem cell division protein ubiquitination cell morphogenesis positive regulation of cell population proliferation mitotic cell cycle integrin-mediated signaling pathway mitotic metaphase plate congression cell migration negative regulation of canonical Wnt signaling pathway vesicle-mediated transport liver morphogenesis proteasome-mediated ubiquitin-dependent protein catabolic process trophectodermal cellular morphogenesis ubiquitin-dependent protein catabolic process anaphase-promoting complex-dependent catabolic process nuclear protein quality control by the ubiquitin-proteasome system post-translational protein modification transport G1/S transition of mitotic cell cycle SCF-dependent proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein ubiquitination protein destabilization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8452 26554 Ensembl ENSG00000036257 ENSMUSG00000004364 UniProt Q13618 Q9JLV5 RefSeq (mRNA) NM_001257197 NM_001257198 NM_003590 NM_016716 NM_001313728 RefSeq (protein) NP_001244126 NP_001244127 NP_003581 NP_001300657 NP_057925 Location (UCSC) Chr 2: 224.47 – 224.59 Mb Chr 1: 80.24 – 80.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cullin 3 is a protein that in humans is encoded by the CUL3 gene.^[5][6][7]

Cullin 3 protein belongs to the family of cullins which in mammals contains eight proteins (Cullin 1, Cullin 2, Cullin 3, Cullin 4A, Cullin 4B, Cullin 5, Cullin 7 and Cullin 9).^[8] Cullin proteins are an evolutionarily conserved family of proteins throughout yeast, plants and mammals.^[9]