CUL5

CUL5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DPL, 3DQV, 4JGH, 4N9F
Identifiers
Aliases	CUL5, VACM-1, VACM1, cullin 5, CUL-5
External IDs	OMIM: 601741; MGI: 1922967; HomoloGene: 2597; GeneCards: CUL5; OMA:CUL5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	108,107,761 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	53,581,314 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; glutes; ; muscle of arm; ; biceps brachii; ; triceps brachii muscle; ; deltoid muscle; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; thoracic diaphragm; ; Epithelium of choroid plexus;
	Top expressed in
	Rostral migratory stream; ; morula; ; tail of embryo; ; zygote; ; spermatid; ; ascending aorta; ; aortic valve; ; spermatocyte; ; muscle of thigh; ; genital tubercle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin protein ligase binding; ubiquitin protein ligase activity; calcium channel activity; ubiquitin-protein transferase activity; signaling receptor activity;
Cellular component	cullin-RING ubiquitin ligase complex; cytosol; Cul5-RING ubiquitin ligase complex; Cul4-RING E3 ubiquitin ligase complex; SCF ubiquitin ligase complex;
Biological process	intrinsic apoptotic signaling pathway; cell population proliferation; ubiquitin-dependent protein catabolic process; negative regulation of cell population proliferation; protein ubiquitination; viral process; ERBB2 signaling pathway; calcium ion transmembrane transport; cellular response to DNA damage stimulus; post-translational protein modification; G1/S transition of mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8065
	75717
	ENSG00000166266
	ENSMUSG00000032030
	Q93034
	Q9D5V5
	NM_003478
	NM_001161618; NM_027807
	NP_003469
	NP_001155090; NP_082083
	Wikidata
View/Edit Human	View/Edit Mouse

Cullin-5 is a protein that in humans is encoded by the CUL5 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166266 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032030 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM (Aug 1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family". Cell. 85 (6): 829–39. doi:10.1016/S0092-8674(00)81267-2. PMID 8681378. S2CID 15805562.
^ Byrd PJ, Stankovic T, McConville CM, Smith AD, Cooper PR, Taylor AM (May 1997). "Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23". Genome Res. 7 (1): 71–5. doi:10.1101/gr.7.1.71. PMID 9037604.
^ "Entrez Gene: CUL5 cullin 5".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166266 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032030 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8681378-5] Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM (Aug 1996). "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family". Cell. 85 (6): 829–39. doi:10.1016/S0092-8674(00)81267-2. PMID 8681378. S2CID 15805562.

[pmid9037604-6] Byrd PJ, Stankovic T, McConville CM, Smith AD, Cooper PR, Taylor AM (May 1997). "Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23". Genome Res. 7 (1): 71–5. doi:10.1101/gr.7.1.71. PMID 9037604.

[entrez-7] "Entrez Gene: CUL5 cullin 5".

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