CXCL10

CXCL10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1O80, 1LV9, 1O7Y, 1O7Z
Identifiers
Aliases	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine ligand 10, C-X-C motif chemokine 10
External IDs	OMIM: 147310; MGI: 1352450; HomoloGene: 1203; GeneCards: CXCL10; OMA:CXCL10 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q21.1 Start 76,021,118 bp[1] End 76,023,497 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 E2|5 46.57 cM Start 92,494,497 bp[2] End 92,496,748 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in appendix testicle decidua lymph node rectum monocyte granulocyte olfactory zone of nasal mucosa smooth muscle tissue epithelium of nasopharynx Top expressed in mesenteric lymph nodes thymus spleen spermatocyte optic nerve embryo right kidney subcutaneous adipose tissue embryo granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity heparin binding CXCR3 chemokine receptor binding chemokine activity protein binding cAMP-dependent protein kinase regulator activity signaling receptor binding chemoattractant activity Cellular component extracellular region external side of plasma membrane extracellular space intracellular anatomical structure Biological process regulation of endothelial tube morphogenesis negative regulation of myoblast differentiation cellular response to heat response to vitamin D positive regulation of cell migration T cell chemotaxis chemokine-mediated signaling pathway cell-cell signaling response to virus muscle organ development positive regulation of monocyte chemotaxis positive regulation of release of sequestered calcium ion into cytosol endothelial cell activation positive regulation of cAMP-mediated signaling regulation of T cell chemotaxis blood circulation chemotaxis positive regulation of leukocyte chemotaxis cell surface receptor signaling pathway response to lipopolysaccharide negative regulation of myoblast fusion defense response to virus regulation of cell population proliferation immune response positive regulation of cell population proliferation response to auditory stimulus negative regulation of angiogenesis response to cold cellular response to lipopolysaccharide response to gamma radiation positive regulation of T cell migration signal transduction positive regulation of transcription by RNA polymerase II regulation of protein kinase activity defense response inflammatory response antimicrobial humoral immune response mediated by antimicrobial peptide regulation of signaling receptor activity G protein-coupled receptor signaling pathway cytokine-mediated signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway response to bacterium neutrophil chemotaxis leukocyte chemotaxis positive chemotaxis regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3627 15945 Ensembl ENSG00000169245 ENSMUSG00000034855 UniProt P02778 P17515 RefSeq (mRNA) NM_001565 NM_021274 RefSeq (protein) NP_001556 NP_067249 Location (UCSC) Chr 4: 76.02 – 76.02 Mb Chr 5: 92.49 – 92.5 Mb PubMed search [3] [4]
Wikidata
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C-X-C motif chemokine ligand 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is an 8.7 kDa protein that in humans is encoded by the CXCL10 gene.^[5][6] C-X-C motif chemokine 10 is a small cytokine belonging to the CXC chemokine family.