CXCR3

CXCR3
Identifiers
Aliases	CXCR3, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR, C-X-C motif chemokine receptor 3, CD182
External IDs	OMIM: 300574; MGI: 1277207; HomoloGene: 1153; GeneCards: CXCR3; OMA:CXCR3 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	71,618,511 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	100,777,875 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; testicle; ; lymph node; ; blood; ; spleen; ; appendix; ; mucosa of transverse colon; ; bone marrow; ; duodenum; ; gallbladder;
	Top expressed in
	secondary oocyte; ; zygote; ; primary oocyte; ; mesenteric lymph nodes; ; submandibular gland; ; blood; ; spleen; ; embryo; ; stroma of bone marrow; ; granulocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	C-X-C chemokine receptor activity; G protein-coupled receptor activity; C-X-C chemokine binding; signal transducer activity; chemokine binding; chemokine receptor activity; protein binding; signaling receptor activity; C-C chemokine receptor activity; C-C chemokine binding;
Cellular component	cytoplasm; integral component of membrane; membrane; integral component of plasma membrane; cell surface; external side of plasma membrane; plasma membrane; intracellular anatomical structure;
Biological process	negative regulation of execution phase of apoptosis; positive regulation of execution phase of apoptosis; positive regulation of cytosolic calcium ion concentration; T cell chemotaxis; chemokine-mediated signaling pathway; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of cAMP-mediated signaling; regulation of leukocyte migration; positive regulation of angiogenesis; negative regulation of endothelial cell proliferation; cell surface receptor signaling pathway; cell adhesion; positive regulation of chemotaxis; angiogenesis; positive regulation of cell population proliferation; chemokine (C-C motif) ligand 11 production; negative regulation of angiogenesis; inflammatory response; calcium-mediated signaling; positive regulation of transcription by RNA polymerase II; signal transduction; apoptotic process; chemotaxis; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; immune response; cell chemotaxis; regulation of cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	2833
	12766
	ENSG00000186810
	ENSMUSG00000050232
	P49682
	O88410
	NM_001142797; NM_001504
	NM_009910
	NP_001136269; NP_001495
	NP_034040
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine receptor CXCR3 is a Gα_i protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183. There are three isoforms of CXCR3 in humans: CXCR3-A, CXCR3-B and chemokine receptor 3-alternative (CXCR3-alt).^[5] CXCR3-A binds to the CXC chemokines CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (I-TAC)^[6] whereas CXCR3-B can also bind to CXCL4 in addition to CXCL9, CXCL10, and CXCL11.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186810 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050232 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Altara R, Manca M, Brandão RD, Zeidan A, Booz GW, Zouein FA (April 2016). "Emerging importance of chemokine receptor CXCR3 and its ligands in cardiovascular diseases". Clinical Science. 130 (7): 463–478. doi:10.1042/CS20150666. PMID 26888559.
^ Clark-Lewis I, Mattioli I, Gong JH, Loetscher P (January 2003). "Structure-function relationship between the human chemokine receptor CXCR3 and its ligands". The Journal of Biological Chemistry. 278 (1): 289–295. doi:10.1074/jbc.M209470200. PMID 12417585.
^ Lasagni L, Francalanci M, Annunziato F, Lazzeri E, Giannini S, Cosmi L, et al. (June 2003). "An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4". The Journal of Experimental Medicine. 197 (11): 1537–1549. doi:10.1084/jem.20021897. PMC 2193908. PMID 12782716.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186810 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050232 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[clinsci.org-5] Altara R, Manca M, Brandão RD, Zeidan A, Booz GW, Zouein FA (April 2016). "Emerging importance of chemokine receptor CXCR3 and its ligands in cardiovascular diseases". Clinical Science. 130 (7): 463–478. doi:10.1042/CS20150666. PMID 26888559.

[pmid12417585-6] Clark-Lewis I, Mattioli I, Gong JH, Loetscher P (January 2003). "Structure-function relationship between the human chemokine receptor CXCR3 and its ligands". The Journal of Biological Chemistry. 278 (1): 289–295. doi:10.1074/jbc.M209470200. PMID 12417585.

[pmid12782716-7] Lasagni L, Francalanci M, Annunziato F, Lazzeri E, Giannini S, Cosmi L, et al. (June 2003). "An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4". The Journal of Experimental Medicine. 197 (11): 1537–1549. doi:10.1084/jem.20021897. PMC 2193908. PMID 12782716.

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