CXCR6

CXCR6
Identifiers
Aliases	CXCR6, BONZO, CD186, STRL33, TYMSTR, C-X-C motif chemokine receptor 6
External IDs	OMIM: 605163; MGI: 1934582; HomoloGene: 38197; GeneCards: CXCR6; OMA:CXCR6 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	45,948,351 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	123,640,825 bp
RNA expression pattern
	Top expressed in
	spleen; ; lymph node; ; amniotic fluid; ; gallbladder; ; appendix; ; blood; ; tonsil; ; mucosa of transverse colon; ; granulocyte; ; epithelium of colon;
	Top expressed in
	thymus; ; embryo; ; embryo; ; mesenteric lymph nodes; ; spleen; ; blastocyst; ; blood; ; subcutaneous adipose tissue; ; right kidney; ; duodenum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	C-X-C chemokine receptor activity; C-X-C chemokine binding; G protein-coupled receptor activity; chemokine receptor activity; signal transducer activity; coreceptor activity; C-C chemokine receptor activity; chemokine binding; C-C chemokine binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; intracellular anatomical structure; external side of plasma membrane;
Biological process	viral genome replication; chemotaxis; chemokine-mediated signaling pathway; G protein-coupled receptor signaling pathway; inflammatory response; signal transduction; immune response; positive regulation of cytosolic calcium ion concentration; calcium-mediated signaling; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	10663
	80901
	ENSG00000172215
	ENSMUSG00000048521
	O00574
	Q9EQ16
	NM_006564
	NM_030712
	NP_006555
	NP_109637
	Wikidata
View/Edit Human	View/Edit Mouse

C-X-C chemokine receptor type 6 is a protein that in humans is encoded by the CXCR6 gene.^[5]^[6]^[7] CXCR6 has also recently been designated CD186 (cluster of differentiation 186).

CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.^[5]^[6]^[7]^[8] It is a minor coreceptor for HIV-1, nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV, CXCR6 may be a major coreceptor.^[8] CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172215 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048521 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM (June 1997). "STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1". The Journal of Experimental Medicine. 185 (11): 2015–23. doi:10.1084/jem.185.11.2015. PMC 2196334. PMID 9166430.
^ ^a ^b Deng HK, Unutmaz D, KewalRamani VN, Littman DR (July 1997). "Expression cloning of new receptors used by simian and human immunodeficiency viruses". Nature. 388 (6639): 296–300. Bibcode:1997Natur.388..296D. doi:10.1038/40894. PMID 9230441. S2CID 4369660.
^ ^a ^b "Entrez Gene: CXCR6 chemokine (C-X-C motif) receptor 6".
^ ^a ^b Elliott ST, Wetzel KS, Francella N, Bryan S, Romero DC, Riddick NE, Shaheen F, Vanderford T, Derdeyn CA, Silvestri G, Paiardini M, Collman RG (September 2015). "Dualtropic CXCR6/CCR5 Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabey Primary Lymphocytes: Distinct Coreceptor Use in Natural versus Pathogenic Hosts of SIV". Journal of Virology. 89 (18): 9252–61. doi:10.1128/JVI.01236-15. PMC 4542357. PMID 26109719.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172215 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048521 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Liao_1997-5] Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM (June 1997). "STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1". The Journal of Experimental Medicine. 185 (11): 2015–23. doi:10.1084/jem.185.11.2015. PMC 2196334. PMID 9166430.

[Deng_1997-6] Deng HK, Unutmaz D, KewalRamani VN, Littman DR (July 1997). "Expression cloning of new receptors used by simian and human immunodeficiency viruses". Nature. 388 (6639): 296–300. Bibcode:1997Natur.388..296D. doi:10.1038/40894. PMID 9230441. S2CID 4369660.

[entrez-7] "Entrez Gene: CXCR6 chemokine (C-X-C motif) receptor 6".

[Elliott_2014-8] Elliott ST, Wetzel KS, Francella N, Bryan S, Romero DC, Riddick NE, Shaheen F, Vanderford T, Derdeyn CA, Silvestri G, Paiardini M, Collman RG (September 2015). "Dualtropic CXCR6/CCR5 Simian Immunodeficiency Virus (SIV) Infection of Sooty Mangabey Primary Lymphocytes: Distinct Coreceptor Use in Natural versus Pathogenic Hosts of SIV". Journal of Virology. 89 (18): 9252–61. doi:10.1128/JVI.01236-15. PMC 4542357. PMID 26109719.

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