CXC chemokine receptors

CXCR1
Identifiers
SymbolIL8RA
NCBI gene3577
OMIM146929
RefSeqNM_000634
UniProtP25024
Other data
LocusChr. 2 q35
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CXCR2
Identifiers
SymbolIL8RB
NCBI gene3579
OMIM146928
RefSeqNM_001557
UniProtP25025
Other data
LocusChr. 2 q35
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StructuresSwiss-model
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CXCR3
Identifiers
SymbolCXCR3
NCBI gene2833
OMIM300574
RefSeqNM_001504
UniProtP49682
Other data
LocusChr. X q13
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CXCR4
Identifiers
SymbolCXCR4
NCBI gene7852
OMIM162643
RefSeqNM_001008540
UniProtP61073
Other data
LocusChr. 2 q21
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CXCR5
Identifiers
SymbolBLR1
NCBI gene643
OMIM601613
RefSeqNM_001716
UniProtP32302
Other data
LocusChr. 11 q23
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CXCR6
Identifiers
SymbolCXCR6
NCBI gene10663
OMIM605163
RefSeqNM_006564
UniProtO00574
Other data
LocusChr. 3 p21
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CXC chemokine receptors are integral membrane proteins that specifically bind and respond to cytokines of the CXC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins, since they span the cell membrane seven times. There are currently six known CXC chemokine receptors in mammals, named CXCR1 through CXCR6.[1][2]

  1. ^ Bachelerie, Françoise; Graham, Gerard J; Locati, Massimo; Mantovani, Alberto; Murphy, Philip M; Nibbs, Robert; Rot, Antal; Sozzani, Silvano; Thelen, Marcus (2015). "An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15". British Journal of Pharmacology. 172 (16): 3945–3949. doi:10.1111/bph.13182. ISSN 0007-1188. PMC 4543604. PMID 25958743.
  2. ^ "Gene group: C-X-C motif chemokine receptors (CXCR)". HUGO Gene Nomenclature Committee.