CYC1

CYC1
Identifiers
Aliases	CYC1, MC3DN6, UQCR4, cytochrome c1
External IDs	OMIM: 123980; MGI: 1913695; HomoloGene: 55617; GeneCards: CYC1; OMA:CYC1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	144,097,525 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	76,230,460 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; left ventricle; ; myocardium of left ventricle; ; mucosa of transverse colon; ; muscle of thigh; ; thoracic diaphragm; ; body of tongue; ; gastrocnemius muscle; ; right auricle; ; right ventricle;
	Top expressed in
	Ileal epithelium; ; interventricular septum; ; extraocular muscle; ; thoracic diaphragm; ; extensor digitorum longus muscle; ; masseter muscle; ; plantaris muscle; ; digastric muscle; ; myocardium of ventricle; ; soleus muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	electron transfer activity; heme binding; metal ion binding;
Cellular component	integral component of membrane; respirasome; nucleus; mitochondrion; mitochondrial inner membrane; membrane; mitochondrial respiratory chain complex III;
Biological process	response to glucagon; mitochondrial electron transport, ubiquinol to cytochrome c; mitochondrial ATP synthesis coupled proton transport;
	Sources:Amigo / QuickGO
Orthologs
	1537
	66445
	ENSG00000179091
	ENSMUSG00000022551
	P08574
	Q9D0M3
	NM_001916
	NM_025567
	NP_001907
	NP_079843
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome c1, heme protein, mitochondrial (CYC1), also known as UQCR4, MC3DN6, Complex III subunit 4, Cytochrome b-c1 complex subunit 4, or Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit is a protein that in humans is encoded by the CYC1 gene. CYC1 is a respiratory subunit of Ubiquinol Cytochrome c Reductase (complex III), which is located in the inner mitochondrial membrane and is part of the electron transport chain. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear, type 6.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179091 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022551 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CYC1 cytochrome c-1".
^ "CYC1 - Cytochrome c1, heme protein, mitochondrial precursor - Homo sapiens (Human) - CYC1 gene & protein". www.uniprot.org. Retrieved 2018-07-31.
^ "UniProt: the universal protein knowledgebase". Nucleic Acids Research. 45 (D1): D158–D169. January 2017. doi:10.1093/nar/gkw1099. PMC 5210571. PMID 27899622.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000179091 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022551 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CYC1 cytochrome c-1".

[:0-6] "CYC1 - Cytochrome c1, heme protein, mitochondrial precursor - Homo sapiens (Human) - CYC1 gene & protein". www.uniprot.org. Retrieved 2018-07-31.

[:3-7] "UniProt: the universal protein knowledgebase". Nucleic Acids Research. 45 (D1): D158–D169. January 2017. doi:10.1093/nar/gkw1099. PMC 5210571. PMID 27899622.

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