CYP24A1

CYP24A1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3K9V, 3K9Y
Identifiers
Aliases	CYP24A1, CP24, CYP24, HCAI, P450-CC24, cytochrome P450 family 24 subfamily A member 1, HCINF1
External IDs	OMIM: 126065; MGI: 88593; HomoloGene: 68094; GeneCards: CYP24A1; OMA:CYP24A1 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	54,173,986 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	170,339,065 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; secondary oocyte; ; testicle; ; mucosa of urinary bladder; ; human kidney; ; epithelium of nasopharynx; ; gonad; ; gingival epithelium; ; palpebral conjunctiva; ; tonsil;
	Top expressed in
	right kidney; ; human kidney; ; renal cortex; ; proximal tubule; ; corneal stroma; ; embryo; ; epiblast; ; axial skeleton; ; efferent ductule; ; lactiferous gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; 25-hydroxycholecalciferol-24-hydroxylase activity; metal ion binding; monooxygenase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity; 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity;
Cellular component	plasma membrane; nucleoplasm; mitochondrion; nucleus; mitochondrial outer membrane;
Biological process	response to vitamin D; vitamin D metabolic process; vitamin metabolic process; osteoblast differentiation; vitamin D catabolic process; vitamin D receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1591
	13081
	ENSG00000019186
	ENSMUSG00000038567
	Q07973
	Q64441
	NM_000782; NM_001128915
	NM_009996
	NP_000773; NP_001122387
	NP_034126
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome P450 family 24 subfamily A member 1 (abbreviated CYP24A1) is a member of the cytochrome P450 superfamily of enzymes encoded by the CYP24A1 gene. It is a mitochondrial monooxygenase which catalyzes reactions including 24-hydroxylation of calcitriol (1,25-dihydroxyvitamin D₃).^[5] It has also been identified as vitamin D3 24-hydroxylase.(EC 1.14.15.16)

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000019186 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038567 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000019186 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038567 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1".

[1]

[2]

[3]

[4]

[5]