CYP26A1

CYP26A1
Identifiers
Aliases	CYP26A1, CP26, CYP26, P450RAI, P450RAI1, cytochrome P450 family 26 subfamily A member 1
External IDs	OMIM: 602239; MGI: 1096359; HomoloGene: 37349; GeneCards: CYP26A1; OMA:CYP26A1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	93,077,885 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	37,689,984 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; olfactory zone of nasal mucosa; ; gonad; ; placenta; ; endometrium; ; prefrontal cortex; ; superior frontal gyrus; ; Brodmann area 9; ; anterior cingulate cortex; ; right frontal lobe;
	Top expressed in
	molar; ; tail of embryo; ; otic vesicle; ; epithelium of lens; ; primitive streak; ; otic placode; ; epiblast; ; embryo; ; left lobe of liver; ; embryonic cloaca;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	iron ion binding; oxygen binding; oxidoreductase activity; retinoic acid binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; metal ion binding; monooxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; retinoic acid 4-hydroxylase activity;
Cellular component	organelle membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; intracellular membrane-bounded organelle;
Biological process	negative regulation of retinoic acid receptor signaling pathway; retinoic acid catabolic process; vitamin metabolic process; xenobiotic metabolic process; sterol metabolic process; response to retinoic acid; response to vitamin A; retinoic acid metabolic process; kidney development;
	Sources:Amigo / QuickGO
Orthologs
	1592
	13082
	ENSG00000095596
	ENSMUSG00000024987
	O43174
	O55127
	NM_057157; NM_000783
	NM_007811
	NP_000774; NP_476498
	NP_031837
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome P450 26A1 is a protein that in humans is encoded by the CYP26A1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000095596 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024987 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ White JA, Beckett-Jones B, Guo YD, Dilworth FJ, Bonasoro J, Jones G, Petkovich M (July 1997). "cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450". The Journal of Biological Chemistry. 272 (30): 18538–41. doi:10.1074/jbc.272.30.18538. PMID 9228017.
^ White JA, Beckett B, Scherer SW, Herbrick JA, Petkovich M (March 1998). "P450RAI (CYP26A1) maps to human chromosome 10q23-q24 and mouse chromosome 19C2-3". Genomics. 48 (2): 270–2. doi:10.1006/geno.1997.5157. PMID 9521883.
^ "Entrez Gene: CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000095596 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024987 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9228017-5] White JA, Beckett-Jones B, Guo YD, Dilworth FJ, Bonasoro J, Jones G, Petkovich M (July 1997). "cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450". The Journal of Biological Chemistry. 272 (30): 18538–41. doi:10.1074/jbc.272.30.18538. PMID 9228017.

[pmid9521883-6] White JA, Beckett B, Scherer SW, Herbrick JA, Petkovich M (March 1998). "P450RAI (CYP26A1) maps to human chromosome 10q23-q24 and mouse chromosome 19C2-3". Genomics. 48 (2): 270–2. doi:10.1006/geno.1997.5157. PMID 9521883.

[entrez-7] "Entrez Gene: CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1".

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