CYP2C8

CYP2C8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCYP2C8, CPC8, CYPIIC8, MP-12/MP-20, cytochrome P450 family 2 subfamily C member 8, CYP2C8DM
External IDsOMIM: 601129; MGI: 1306818; HomoloGene: 117948; GeneCards: CYP2C8; OMA:CYP2C8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000770
NM_001198853
NM_001198854
NM_001198855
NM_030878

NM_010003
NM_001373937

RefSeq (protein)

NP_000761
NP_001185782
NP_001185783
NP_001185784

NP_034133
NP_001360866

Location (UCSC)Chr 10: 95.04 – 95.07 MbChr 19: 39.5 – 39.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytochrome P4502C8 (CYP2C8) is a member of the cytochrome P450 mixed-function oxidase system involved in the metabolism of xenobiotics in the body. Cytochrome P4502C8 also possesses epoxygenase activity, i.e. it metabolizes long-chain polyunsaturated fatty acids, e.g. arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, and linoleic acid to their biologically active epoxides.[5]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138115Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025003Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Westphal C, Konkel A, Schunck WH (Nov 2011). "CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease?". Prostaglandins & Other Lipid Mediators. 96 (1–4): 99–108. doi:10.1016/j.prostaglandins.2011.09.001. PMID 21945326.