CYP3A43

CYP3A43
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesCYP3A43, cytochrome P450 family 3 subfamily A member 43
External IDsOMIM: 606534; HomoloGene: 136124; GeneCards: CYP3A43; OMA:CYP3A43 - orthologs
EC number1.14.14.56
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278921
NM_022820
NM_057095
NM_057096

n/a

RefSeq (protein)

NP_001265850
NP_073731
NP_476436
NP_476437

n/a

Location (UCSC)Chr 7: 99.83 – 99.87 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene.[3][4][5]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms.[5]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000021461Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG (Feb 2001). "cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450". Mol Pharmacol. 59 (2): 386–92. doi:10.1124/mol.59.2.386. PMID 11160876.
  4. ^ Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L (Mar 2001). "Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene". Pharmacogenetics. 11 (2): 111–21. doi:10.1097/00008571-200103000-00002. PMID 11266076.
  5. ^ a b "Entrez Gene: CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43".