CYP4A11

CYP4A11
Identifiers
Aliases	CYP4A11, CP4Y, CYP4A2, CYP4AII, cytochrome P450 family 4 subfamily A member 11, CYPIVA11
External IDs	OMIM: 601310; MGI: 88611; HomoloGene: 128044; GeneCards: CYP4A11; OMA:CYP4A11 - orthologs
EC number	1.14.14.80
Gene location (Human)
Chr.	Chromosome 1 (human)
End	46,941,484 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	115,390,846 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; Achilles tendon; ; sural nerve; ; human kidney; ; gonad; ; renal cortex; ; duodenum; ; gallbladder; ; subcutaneous adipose tissue; ; superior frontal gyrus;
	Top expressed in
	left lobe of liver; ; right kidney; ; human kidney; ; gallbladder; ; proximal tubule; ; duodenum; ; sexually immature organism; ; primary visual cortex; ; muscle of thigh; ; embryo;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	iron ion binding; leukotriene-B4 20-monooxygenase activity; arachidonic acid epoxygenase activity; metal ion binding; alkane 1-monooxygenase activity; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity; monooxygenase activity;
Cellular component	cytoplasm; organelle membrane; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; membrane; apical plasma membrane; endoplasmic reticulum;
Biological process	leukotriene metabolic process; epoxygenase P450 pathway; fatty acid metabolic process; pressure natriuresis; omega-hydroxylase P450 pathway; renal water homeostasis; positive regulation of icosanoid secretion; sodium ion homeostasis; long-chain fatty acid metabolic process; leukotriene B4 catabolic process; arachidonic acid metabolic process; regulation of lipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	1579
	13117
	ENSG00000187048
	ENSMUSG00000066072
	Q02928
	O88833
	NM_000778; NM_001319155; NM_001363587
	NM_010011
	NP_000769; NP_001306084; NP_001350516
	NP_034141
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome P450 4A11 is a protein that in humans is codified by the CYP4A11 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000187048 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066072 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Palmer CN, Richardson TH, Griffin KJ, Hsu MH, Muerhoff AS, Clark JE, Johnson EF (Feb 1993). "Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli". Biochimica et Biophysica Acta. 1172 (1–2): 161–6. doi:10.1016/0167-4781(93)90285-L. PMID 7679927.
^ "Entrez Gene: CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000187048 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000066072 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7679927-5] Palmer CN, Richardson TH, Griffin KJ, Hsu MH, Muerhoff AS, Clark JE, Johnson EF (Feb 1993). "Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli". Biochimica et Biophysica Acta. 1172 (1–2): 161–6. doi:10.1016/0167-4781(93)90285-L. PMID 7679927.

[entrez-6] "Entrez Gene: CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11".

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