Caco-2

Phase contrast micrograph of confluent Caco-2 cells

Caco-2 (from Cancer coli, "colon cancer") is an immortalized cell line of human colorectal adenocarcinoma cells. It is primarily used as a model of the intestinal epithelial barrier.[1] In culture, Caco-2 cells spontaneously differentiate into a heterogeneous mixture of intestinal epithelial cells.[1] It was developed in 1977 by Jorgen Fogh at the Sloan-Kettering Institute for Cancer Research.[2]

  1. ^ a b Lea, Tor (2015). "Caco-2 Cell Line". The Impact of Food Bioactives on Health: 103–111. doi:10.1007/978-3-319-16104-4_10. ISBN 978-3-319-15791-7. PMID 29787057.
  2. ^ Fogh, Jørgen; Fogh, Jens M.; Orfeo, Thomas (July 1977). "One Hundred and Twenty-Seven Cultured Human Tumor Cell Lines Producing Tumors in Nude Mice23". JNCI: Journal of the National Cancer Institute. 59 (1): 221–226. doi:10.1093/jnci/59.1.221. PMID 327080.