Cadherin-1

CDH1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO, cadherin 1, BCDS1, E-cadherin, uvomorulin
External IDsOMIM: 192090; MGI: 88354; HomoloGene: 20917; GeneCards: CDH1; OMA:CDH1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004360
NM_001317184
NM_001317185
NM_001317186

NM_009864

RefSeq (protein)

NP_001304113
NP_001304114
NP_001304115
NP_004351

NP_033994

Location (UCSC)Chr 16: 68.74 – 68.84 MbChr 8: 107.33 – 107.4 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cadherin-1 or Epithelial cadherin (E-cadherin), (not to be confused with the APC/C activator protein CDH1) is a protein that in humans is encoded by the CDH1 gene.[5] Mutations are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. CDH1 has also been designated as CD324 (cluster of differentiation 324). It is a tumor suppressor gene.[6][7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000039068Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000303Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Huntsman DG, Caldas C (Mar 1999). "Assignment1 of the E-cadherin gene (CDH1) to chromosome 16q22.1 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 83 (1–2): 82–83. doi:10.1159/000015134. PMID 9925936. S2CID 39971762.
  6. ^ Semb H, Christofori G (December 1998). "The tumor-suppressor function of E-cadherin". American Journal of Human Genetics. 63 (6): 1588–93. doi:10.1086/302173. PMC 1377629. PMID 9837810.
  7. ^ Wong AS, Gumbiner BM (June 2003). "Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin". The Journal of Cell Biology. 161 (6): 1191–1203. doi:10.1083/jcb.200212033. PMC 2173007. PMID 12810698.