Cadherin-2 also known as Neural cadherin (N-cadherin), is a protein that in humans is encoded by the CDH2gene.[5][6][7] CDH2 has also been designated as CD325 (cluster of differentiation 325).
Cadherin-2 is a transmembraneprotein expressed in multiple tissues and functions to mediate cell–cell adhesion. In cardiac muscle, Cadherin-2 is an integral component in adherens junctions residing at intercalated discs, which function to mechanically and electrically couple adjacent cardiomyocytes. Alterations in expression and integrity of Cadherin-2 has been observed in various forms of disease, including human dilated cardiomyopathy. Variants in CDH2 have also been identified to cause a syndromic neurodevelopmental disorder.[8]
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^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"UniProt". www.uniprot.org. Retrieved 26 August 2022.
^Walsh FS, Barton CH, Putt W, Moore SE, Kelsell D, Spurr N, Goodfellow PN (September 1990). "N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene". Journal of Neurochemistry. 55 (3): 805–12. doi:10.1111/j.1471-4159.1990.tb04563.x. PMID2384753. S2CID29840435.