Calcium-induced calcium release

Calcium-induced calcium release (CICR) describes a biological process whereby calcium is able to activate calcium release from intracellular Ca²⁺ stores (e.g., endoplasmic reticulum or sarcoplasmic reticulum). Although CICR was first proposed for skeletal muscle in the 1970s,^[1] it is now known that CICR is unlikely to be the primary mechanism for activating SR calcium release. Instead, CICR is thought to be crucial for excitation-contraction coupling in cardiac muscle.^[2] It is now obvious that CICR is a widely occurring cellular signaling process present even in many non-muscle cells, such as in the insulin-secreting pancreatic beta cells,^[3] epithelium, and many other cells.^[4] Since CICR is a positive-feedback system, it has been of great interest to elucidate the mechanism(s) responsible for its termination.

^ Endo M (January 1977). "Calcium release from the sarcoplasmic reticulum". Physiological Reviews. 57 (1): 71–108. doi:10.1152/physrev.1977.57.1.71. PMID 13441.
^ Fabiato A (July 1983). "Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum". The American Journal of Physiology. 245 (1): C1-14. doi:10.1152/ajpcell.1983.245.1.C1. PMID 6346892.
^ Islam MS, Rorsman P, Berggren PO (January 1992). "Ca(2+)-induced Ca2+ release in insulin-secreting cells". FEBS Letters. 296 (3): 287–91. doi:10.1016/0014-5793(92)80306-2. PMID 1537406. S2CID 86591372.
^ Koulen P (January 2003). "Chapter 26 - Using bilayer lipid membranes to investigate the pharmacology of intracellular calcium channels". In Tien HT, Ottova-Leitmannova A (eds.). Membrane Science and Technology. Planar Lipid Bilayers (BLMs) and Their Applications. Vol. 7. Elsevier. pp. 723–734. doi:10.1016/s0927-5193(03)80050-5. ISBN 9780444509406.

[1] Endo M (January 1977). "Calcium release from the sarcoplasmic reticulum". Physiological Reviews. 57 (1): 71–108. doi:10.1152/physrev.1977.57.1.71. PMID 13441.

[2] Fabiato A (July 1983). "Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum". The American Journal of Physiology. 245 (1): C1-14. doi:10.1152/ajpcell.1983.245.1.C1. PMID 6346892.

[3] Islam MS, Rorsman P, Berggren PO (January 1992). "Ca(2+)-induced Ca2+ release in insulin-secreting cells". FEBS Letters. 296 (3): 287–91. doi:10.1016/0014-5793(92)80306-2. PMID 1537406. S2CID 86591372.

[:0-4] Koulen P (January 2003). "Chapter 26 - Using bilayer lipid membranes to investigate the pharmacology of intracellular calcium channels". In Tien HT, Ottova-Leitmannova A (eds.). Membrane Science and Technology. Planar Lipid Bilayers (BLMs) and Their Applications. Vol. 7. Elsevier. pp. 723–734. doi:10.1016/s0927-5193(03)80050-5. ISBN 9780444509406.

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