Calpain

Calpain
Crystal structure of the peptidase core of Calpain II.
Identifiers
SymbolCalpain
PfamPF00648
Pfam clanCL0125
InterProIPR001300
SMARTCysPc
PROSITEPDOC50203
MEROPSC2
SCOP21mdw / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1tl9​ A:55-354; 1kxr​ B:55-354; 1tlo​ A:55-354; 2ary​ B:55-354; 1zcm​ A:55-353; 1mdw​ B:45-344; 1u5i​ A:45-344; 1kfx​ L:45-344; 1kfu​ L:45-344; 1ziv​ A:42-337
calpain-1
Identifiers
EC no.3.4.22.52
CAS no.689772-75-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
calpain-2
Identifiers
EC no.3.4.22.53
CAS no.702693-80-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

A calpain (/ˈkælpeɪn/;[1] EC 3.4.22.52, EC 3.4.22.53) is a protein belonging to the family of calcium-dependent, non-lysosomal cysteine proteases (proteolytic enzymes) expressed ubiquitously in mammals and many other organisms. Calpains constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the calpain proteases, the small regulatory subunit CAPNS1, also known as CAPN4, and the endogenous calpain-specific inhibitor, calpastatin.

  1. ^ "the definition of calpain". Dictionary.com. Retrieved 23 April 2018.