Calponin

Calponin Homology Domain
CH domain from H.Sapiends Calponin 1. PDB 1wyp
Identifiers
SymbolCH
PfamPF00307
Pfam clanCL0188
InterProIPR001715
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
calponin 1, basic, smooth muscle
Solution structure of the CH domain of human Calponin 1. Rainbow colored cartoon (N-terminus = blue, C-terminus = red).[1]
Identifiers
SymbolCNN1
NCBI gene1264
HGNC2155
OMIM600806
PDB1WYP
RefSeqNM_001299
UniProtP51911
Other data
LocusChr. 19 p13.2-13.1
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StructuresSwiss-model
DomainsInterPro
calponin 2
Identifiers
SymbolCNN2
NCBI gene1265
HGNC2156
OMIM602373
RefSeqNM_004368
UniProtQ99439
Other data
LocusChr. 19 p13.3
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StructuresSwiss-model
DomainsInterPro
calponin 3, acidic
Identifiers
SymbolCNN3
NCBI gene1266
HGNC2157
OMIM602374
RefSeqNM_001839
UniProtQ6FHA7
Other data
LocusChr. 1 p22-p21
Search for
StructuresSwiss-model
DomainsInterPro

Calponin is a calcium binding protein. Calponin tonically inhibits the ATPase activity of myosin in smooth muscle. Phosphorylation of calponin by a protein kinase, which is dependent upon calcium binding to calmodulin, releases the calponin's inhibition of the smooth muscle ATPase.

  1. ^ PDB: 1WYP​; Tomizawa T, Kigawa T, Koshiba S, Inoue M, Yokoyama S. "RCSB PDB - 1WYP Structure Summary". RCSB Protein Data Bank. doi:10.2210/pdb1wyp/pdb. {{cite journal}}: Cite journal requires |journal= (help)