Calponin 1

CNN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WYP
Identifiers
Aliases	CNN1, HEL-S-14, SMCC, Sm-Calp, calponin 1
External IDs	OMIM: 600806; MGI: 104979; HomoloGene: 995; GeneCards: CNN1; OMA:CNN1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	11,550,323 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	22,020,926 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; popliteal artery; ; tibial arteries; ; body of uterus; ; tail of epididymis; ; right coronary artery; ; seminal vesicula; ; gastric mucosa; ; myometrium; ; urethra;
	Top expressed in
	ascending aorta; ; tunica media of zone of aorta; ; cervix; ; aortic valve; ; belly cord; ; left colon; ; seminal vesicula; ; pyloric antrum; ; atrium; ; migratory enteric neural crest cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	actin binding; calmodulin binding; protein binding;
Cellular component	cytoskeleton; focal adhesion;
Biological process	actomyosin structure organization; regulation of smooth muscle contraction; negative regulation of vascular associated smooth muscle cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	1264
	12797
	ENSG00000130176
	ENSMUSG00000001349
	P51911
	Q08091
	NM_001299; NM_001308341; NM_001308342
	NM_009922
	NP_001290; NP_001295270; NP_001295271
	NP_034052
	Wikidata
View/Edit Human	View/Edit Mouse

Calponin 1 is a basic smooth muscle protein that in humans is encoded by the CNN1 gene.^[5]

The CNN1 gene is located at 19p13.2-p13.1 in the human chromosomal genome and contains 7 exons, encoding the protein calponin 1, an actin filament-associated regulatory protein.^[6] Human calponin 1 is a 33.2-KDa protein consists of 297 amino acids with an isoelectric point of 9.1,^[7] thus calponin 1 is also known as basic calponin.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130176 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001349 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: calponin 1, basic, smooth muscle".
^ Takahashi K, Abe M, Hiwada K, Kokubu T (December 1988). "A novel troponin T-like protein (calponin) in vascular smooth muscle: interaction with tropomyosin paracrystals". Journal of Hypertension Supplement. 6 (4): S40–3. doi:10.1097/00004872-198812040-00008. PMID 3241227. S2CID 38679688.
^ Gao J, Hwang JM, Jin JP (January 1996). "Complete nucleotide sequence, structural organization, and an alternatively spliced exon of mouse h1-calponin gene". Biochemical and Biophysical Research Communications. 218 (1): 292–7. doi:10.1006/bbrc.1996.0051. PMID 8573148.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130176 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001349 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: calponin 1, basic, smooth muscle".

[Takahashi_1994-6] Takahashi K, Abe M, Hiwada K, Kokubu T (December 1988). "A novel troponin T-like protein (calponin) in vascular smooth muscle: interaction with tropomyosin paracrystals". Journal of Hypertension Supplement. 6 (4): S40–3. doi:10.1097/00004872-198812040-00008. PMID 3241227. S2CID 38679688.

[Gao_1996-7] Gao J, Hwang JM, Jin JP (January 1996). "Complete nucleotide sequence, structural organization, and an alternatively spliced exon of mouse h1-calponin gene". Biochemical and Biophysical Research Communications. 218 (1): 292–7. doi:10.1006/bbrc.1996.0051. PMID 8573148.

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