Calponin 2

CNN2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WYN
Identifiers
Aliases	CNN2, calponin 2
External IDs	OMIM: 602373; MGI: 105093; HomoloGene: 3215; GeneCards: CNN2; OMA:CNN2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,039,068 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,831,896 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; stromal cell of endometrium; ; right ovary; ; right lung; ; left ovary; ; left uterine tube; ; blood; ; upper lobe of left lung; ; right coronary artery; ; thoracic aorta;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; granulocyte; ; mesenteric lymph nodes; ; left lung lobe; ; calvaria; ; blood; ; tibiofemoral joint; ; right lung; ; tunica media of zone of aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	actin binding; calmodulin binding; cadherin binding;
Cellular component	extracellular exosome; cytoskeleton; membrane; focal adhesion; stress fiber; cell-cell junction; extracellular region; specific granule lumen; tertiary granule lumen;
Biological process	actomyosin structure organization; cellular response to mechanical stimulus; cytoskeleton organization; regulation of actin filament-based process; neutrophil degranulation; interleukin-12-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1265
	12798
	ENSG00000064666
	ENSMUSG00000004665
	Q99439
	Q08093
	NM_201277; NM_001303499; NM_001303501; NM_004368
	NM_007725
	NP_001290428; NP_001290430; NP_004359; NP_958434
	NP_031751
	Wikidata
View/Edit Human	View/Edit Mouse

Calponin 2 is a protein that in humans is encoded by the CNN2 gene.

The CNN2 gene is located at 19p13.3 in the human chromosomal genome,^[5] encoding the protein calponin 2. Calponin 2 is one of the three isoforms of calponin and an actin filament-associated regulatory protein with wide tissue distributions. Human calponin 2 is a 33.7-kDa protein consisting of 309 amino acids with an isoelectric point (pI) of 7.23. Accordingly, it is also known as neutral calponin.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000064666 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004665 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Masuda H, Tanaka K, Takagi M, Ohgami K, Sakamaki T, Shibata N, Takahashi K (1996). "Molecular cloning and characterization of human non-smooth muscle calponin". Journal of Biochemistry. 120 (2): 415–24. doi:10.1093/oxfordjournals.jbchem.a021428. PMID 8889829.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000064666 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004665 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8889829-5] Masuda H, Tanaka K, Takagi M, Ohgami K, Sakamaki T, Shibata N, Takahashi K (1996). "Molecular cloning and characterization of human non-smooth muscle calponin". Journal of Biochemistry. 120 (2): 415–24. doi:10.1093/oxfordjournals.jbchem.a021428. PMID 8889829.

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