Calreticulin

CALR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3POW, 2CLR, 3DOW, 3POS
Identifiers
Aliases	CALR, CRT, HEL-S-99n, RO, SSA, cC1qR, calreticulin
External IDs	OMIM: 109091; MGI: 88252; HomoloGene: 37911; GeneCards: CALR; OMA:CALR - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.13 Start 12,938,578 bp[1] End 12,944,489 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 C3|8 41.21 cM Start 85,568,479 bp[2] End 85,573,563 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium left lobe of thyroid gland right lobe of thyroid gland islet of Langerhans smooth muscle tissue anterior pituitary epithelium of colon rectum upper lobe of left lung mucosa of transverse colon Top expressed in gastrula tail of embryo molar pyloric antrum spermatocyte external carotid artery internal carotid artery genital tubercle epithelium of stomach calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein folding chaperone activity carbohydrate binding hormone binding metal ion binding complement component C1q complex binding mRNA binding iron ion binding unfolded protein binding zinc ion binding integrin binding DNA binding chaperone binding peptide binding androgen receptor binding ubiquitin protein ligase binding RNA binding protein binding Cellular component cytoplasm cytosol endoplasmic reticulum lumen membrane focal adhesion extracellular region perinuclear region of cytoplasm sarcoplasmic reticulum lumen nucleus endocytic vesicle lumen cell surface endoplasmic reticulum extracellular exosome Golgi apparatus intracellular membrane-bounded organelle extracellular matrix intracellular anatomical structure integral component of lumenal side of endoplasmic reticulum membrane sarcoplasmic reticulum smooth endoplasmic reticulum MHC class I peptide loading complex acrosomal vesicle external side of plasma membrane polysome phagocytic vesicle membrane endoplasmic reticulum-Golgi intermediate compartment membrane extracellular space nuclear envelope protein-containing complex endoplasmic reticulum quality control compartment collagen-containing extracellular matrix Biological process negative regulation of neuron differentiation protein folding in endoplasmic reticulum receptor-mediated endocytosis response to organic substance cellular senescence spermatogenesis positive regulation of dendritic cell chemotaxis regulation of apoptotic process cellular response to organic substance positive regulation of phagocytosis negative regulation of intracellular steroid hormone receptor signaling pathway regulation of transcription, DNA-templated negative regulation of retinoic acid receptor signaling pathway cardiac muscle cell differentiation regulation of meiotic nuclear division protein maturation by protein folding positive regulation of cell cycle protein export from nucleus cellular response to lithium ion peptide antigen assembly with MHC class I protein complex antigen processing and presentation of peptide antigen via MHC class I protein stabilization cellular calcium ion homeostasis negative regulation of transcription by RNA polymerase II positive regulation of DNA replication protein folding negative regulation of transcription, DNA-templated cortical actin cytoskeleton organization chaperone-mediated protein folding response to estradiol response to testosterone ATF6-mediated unfolded protein response positive regulation of substrate adhesion-dependent cell spreading sequestering of calcium ion positive regulation of gene expression positive regulation of cell population proliferation protein localization to nucleus glucocorticoid receptor signaling pathway positive regulation of NIK/NF-kappaB signaling antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent negative regulation of translation vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane positive regulation of endothelial cell migration negative regulation of trophoblast cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 811 12317 Ensembl ENSG00000179218 ENSMUSG00000003814 UniProt P27797 P14211 RefSeq (mRNA) NM_004343 NM_007591 RefSeq (protein) NP_004334 NP_031617 Location (UCSC) Chr 19: 12.94 – 12.94 Mb Chr 8: 85.57 – 85.57 Mb PubMed search [3] [4]
Wikidata
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Calreticulin also known as calregulin, CRP55, CaBP3, calsequestrin-like protein, and endoplasmic reticulum resident protein 60 (ERp60) is a protein that in humans is encoded by the CALR gene.^[5][6]

Calreticulin is a multifunctional soluble protein that binds Ca²⁺ ions (a second messenger in signal transduction), rendering it inactive. The Ca²⁺ is bound with low affinity, but high capacity, and can be released on a signal (see inositol trisphosphate). Calreticulin is located in storage compartments associated with the endoplasmic reticulum and is considered an ER resident protein.^[6]

The term "Mobilferrin"^[7] is considered to be the same as calreticulin by some sources.^[8]