Calsenilin

KCNIP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E6W
Identifiers
Aliases	KCNIP3, CSEN, DREAM, KCHIP3, potassium voltage-gated channel interacting protein 3
External IDs	OMIM: 604662; MGI: 1929258; HomoloGene: 8382; GeneCards: KCNIP3; OMA:KCNIP3 - orthologs
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	127,364,014 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Brodmann area 9; ; left lobe of thyroid gland; ; amygdala; ; right lobe of thyroid gland; ; nucleus accumbens; ; caudate nucleus; ; hypothalamus; ; putamen; ; hippocampus proper;
	Top expressed in
	lumbar spinal ganglion; ; primary visual cortex; ; superior frontal gyrus; ; piriform cortex; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; medial dorsal nucleus; ; subiculum; ; prefrontal cortex; ; medial geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; calcium ion binding; sequence-specific DNA binding; potassium channel activity; transcription corepressor activity; voltage-gated ion channel activity; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; potassium channel regulator activity; transmembrane transporter binding;
Cellular component	cytoplasm; axon terminus; cytosol; Golgi apparatus; membrane; voltage-gated potassium channel complex; axon; dendrite; protein-DNA complex; endoplasmic reticulum; nucleus; plasma membrane;
Biological process	regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; regulation of ion transmembrane transport; negative regulation of transcription by RNA polymerase II; ion transport; transcription, DNA-templated; potassium ion transport; potassium ion transmembrane transport; protein localization to plasma membrane; intracellular protein transport; regulation of potassium ion transmembrane transport; signal transduction; apoptotic process; negative regulation of nucleic acid-templated transcription; cardiac conduction;
	Sources:Amigo / QuickGO
Orthologs
	30818
	56461
	n/a
	ENSMUSG00000079056
	Q9Y2W7
	Q9QXT8; P0C092
	NM_001034914; NM_013434
	NM_001111331; NM_001291005; NM_019789
	NP_001030086; NP_038462
	NP_001104801; NP_001277934; NP_062763
	Wikidata
View/Edit Human	View/Edit Mouse

Calsenilin is a protein that in humans is encoded by the KCNIP3 gene.^[4]^[5]^[6]

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079056 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W (October 1998). "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment". Nat Med. 4 (10): 1177–81. doi:10.1038/2673. PMID 9771752. S2CID 10799492.
^ Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR (March 1999). "DREAM is a Ca2+-regulated transcriptional repressor". Nature. 398 (6722): 80–4. Bibcode:1999Natur.398...80C. doi:10.1038/18044. PMID 10078534. S2CID 204991618.
^ "Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin".

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000079056 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9771752-4] Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W (October 1998). "Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment". Nat Med. 4 (10): 1177–81. doi:10.1038/2673. PMID 9771752. S2CID 10799492.

[pmid10078534-5] Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR (March 1999). "DREAM is a Ca2+-regulated transcriptional repressor". Nature. 398 (6722): 80–4. Bibcode:1999Natur.398...80C. doi:10.1038/18044. PMID 10078534. S2CID 204991618.

[entrez-6] "Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin".

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