Mammalian protein found in humans
CNR1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LVQ , 1LVR , 2B0Y , 2KOE , 2MZ3 , 2MZ2 , 2MZA ,%%s1LVQ , 1LVR , 2B0Y , 2KOE
Identifiers Aliases CNR1 , CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR, cannabinoid receptor 1 (brain), cannabinoid receptor 1, cannabinoid CB1 receptor geneExternal IDs OMIM : 114610 ; MGI : 104615 ; HomoloGene : 7273 ; GeneCards : CNR1 ; OMA :CNR1 - orthologs RNA expression patternBgee Human Mouse (ortholog)Top expressed in ganglionic eminence ventricular zone decidua cerebellar vermis paraflocculus of cerebellum frontal pole Region I of hippocampus proper Brodmann area 10 Brodmann area 23 endothelial cell
Top expressed in lobe of cerebellum cerebellar vermis subiculum ventromedial nucleus lateral hypothalamus anterior amygdaloid area dentate gyrus of hippocampal formation granule cell lateral septal nucleus superior frontal gyrus deep cerebellar nuclei
More reference expression data
BioGPS
Wikidata
Cannabinoid receptor 1 (CB1 ), is a G protein-coupled cannabinoid receptor that in humans is encoded by the CNR1 gene .[ 5] The human CB1 receptor is expressed in the peripheral nervous system and central nervous system .[ 5] It is activated by endogenous cannabinoids[ 6] called endocannabinoids , a group of retrograde neurotransmitters that include lipids, such as anandamide and 2-arachidonoylglycerol (2-AG); plant phytocannabinoids , such as docosatetraenoylethanolamide found in wild daga , the compound THC which is an active constituent of the psychoactive drug cannabis ; and synthetic analogs of THC . CB1 is antagonized by the phytocannabinoid tetrahydrocannabivarin (THCV).[ 7] [ 8]
The primary endogenous agonist of the human CB1 receptor is anandamide .[ 5]
^ a b c GRCh38: Ensembl release 89: ENSG00000118432 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044288 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ a b c Abood M, Barth F, Bonner TI, Cabral G, Casellas P, Cravatt BF, et al. (22 August 2018). "CB1 Receptor" . IUPHAR/BPS Guide to Pharmacology . International Union of Basic and Clinical Pharmacology. Retrieved 9 November 2018 .
^ Busquets Garcia A, Soria-Gomez E, Bellocchio L, Marsicano G (24 May 2016). "Cannabinoid receptor type-1: breaking the dogmas" . F1000Research . 5 : 990. doi :10.12688/f1000research.8245.1 . PMC 4879932 . PMID 27239293 .
^ Thomas A, Stevenson LA, Wease KN, Price MR, Baillie G, Ross RA, et al. (December 2005). "Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist" . British Journal of Pharmacology . 146 (7): 917–926. doi :10.1038/sj.bjp.0706414 . PMC 1751228 . PMID 16205722 .
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