Carbohydrate-responsive element-binding protein

MLXIPL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GNT
Identifiers
Aliases	MLXIPL, CHREBP, MIO, MONDOB, WBSCR14, WS-bHLH, bHLHd14, MLX interacting protein like, MLX
External IDs	OMIM: 605678; MGI: 1927999; HomoloGene: 32507; GeneCards: MLXIPL; OMA:MLXIPL - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q11.23 Start 73,593,194 bp[1] End 73,624,543 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 135,118,744 bp[2] End 135,167,236 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver left adrenal cortex right adrenal gland right adrenal cortex right hemisphere of cerebellum subcutaneous adipose tissue gastric mucosa gastrocnemius muscle right testis muscle of thigh Top expressed in crypt of lieberkuhn of small intestine left lobe of liver brown adipose tissue islet of Langerhans muscle of thigh proximal tubule zygote soleus muscle right kidney skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carbohydrate response element binding DNA binding protein dimerization activity protein homodimerization activity DNA-binding transcription factor activity transcription factor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein heterodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex nucleoplasm nucleus cytoplasm cytosol Biological process intracellular signal transduction positive regulation of lipid biosynthetic process regulation of transcription, DNA-templated glucose homeostasis regulation of transcription by RNA polymerase II anatomical structure morphogenesis negative regulation of transcription by RNA polymerase II positive regulation of fatty acid biosynthetic process transcription, DNA-templated positive regulation of transcription, DNA-templated fatty acid homeostasis positive regulation of cell population proliferation negative regulation of peptidyl-serine phosphorylation glucose mediated signaling pathway negative regulation of oxidative phosphorylation negative regulation of transcription, DNA-templated positive regulation of glycolytic process triglyceride homeostasis positive regulation of transcription by RNA polymerase II cellular response to carbohydrate stimulus energy homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51085 58805 Ensembl ENSG00000009950 ENSMUSG00000005373 UniProt Q9NP71 Q99MZ3 RefSeq (mRNA) NM_032951 NM_032952 NM_032953 NM_032954 NM_032994 NM_021455 NM_001359237 RefSeq (protein) NP_116569 NP_116570 NP_116571 NP_116572 NP_067430 NP_001346166 Location (UCSC) Chr 7: 73.59 – 73.62 Mb Chr 5: 135.12 – 135.17 Mb PubMed search [3] [4]
Wikidata
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Carbohydrate-responsive element-binding protein (ChREBP) also known as MLX-interacting protein-like (MLXIPL) is a protein that in humans is encoded by the MLXIPL gene.^[5][6] The protein name derives from the protein's interaction with carbohydrate response element sequences of DNA.