| Cardiac glycoside | |
|---|---|
| Drug class | |
 The general structure of a cardiac glycoside molecule. | |
| Class identifiers | |
| Use | Congestive heart failure |
| ATC code | C01A |
| Biological target | Na+ /K+ -ATPase |
| External links | |
| MeSH | D002301 |
| Legal status | |
| In Wikidata | |
Cardiac glycosides are a class of organic compounds that increase the output force of the heart and decrease its rate of contractions by inhibiting the cellular sodium-potassium ATPase pump.[1] Their beneficial medical uses include treatments for congestive heart failure and cardiac arrhythmias; however, their relative toxicity prevents them from being widely used.[2] Most commonly found as secondary metabolites in several plants such as foxglove plants and milkweed plants, these compounds nevertheless have a diverse range of biochemical effects regarding cardiac cell function and have also been suggested for use in cancer treatment.[3]
- ^ Patel S (December 2016). "Plant-derived cardiac glycosides: Role in heart ailments and cancer management". Biomedicine & Pharmacotherapy. 84: 1036–1041. doi:10.1016/j.biopha.2016.10.030. PMID 27780131.
- ^ Ambrosy AP, Butler J, Ahmed A, Vaduganathan M, van Veldhuisen DJ, Colucci WS, Gheorghiade M (May 2014). "The use of digoxin in patients with worsening chronic heart failure: reconsidering an old drug to reduce hospital admissions" (PDF). Journal of the American College of Cardiology. 63 (18): 1823–1832. doi:10.1016/j.jacc.2014.01.051. PMID 24613328.
- ^ Riganti C, Campia I, Kopecka J, Gazzano E, Doublier S, Aldieri E, et al. (2011-01-01). "Pleiotropic effects of cardioactive glycosides". Current Medicinal Chemistry. 18 (6): 872–885. doi:10.2174/092986711794927685. PMID 21182478.