Cardinal-Infante Afonso of Portugal

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His Eminence Afonso of Portugal Archbishop of Lisbon
Infante of Portugal
Church	Catholic church
Archdiocese	Archdiocese of Lisbon
Appointed	20 February 1523
Term ended	21 April 1540
Predecessor	Martinho da Costa
Successor	Fernando de Meneses
Other post(s)	Bishop of Évora (1523–1540)
Previous post(s)	Bishop of Guarda (1516–1519) Bishop of Viseu (1519–1523)
Orders
Created cardinal	1 July 1517 by Pope Leo X
Rank	Cardinal-Priest
Personal details
Born	23 April 1509 Évora
Died	21 April 1540(1540-04-21) (aged 30) Lisbon
Denomination	Roman Catholicism
Parents	Manuel I of Portugal Maria of Aragon

Cardinal-Infante Afonso (23 April 1509 – 21 April 1540; Portuguese pronunciation: [ɐˈfõsu]; English: Alphonzo) was a Portuguese infante (prince), son of King Manuel I of Portugal and his wife Maria of Aragon.

Because he was the fourth son, after the infantes John, Luís, and Ferdinand, he was assigned by his father to religious life, and he accumulated numerous ecclesiastical benefits even though he did not have the canonical age required to exercise these dignities. He was successively bishop of Guarda, cardinal, bishop of Viseu, bishop of Évora and finally archbishop of Lisbon.