Cariporide

Cariporide
Clinical data
Other namesHOE642
ATC code
  • none
Identifiers
  • N-(Diaminomethylidene)-3-methanesulfonyl-4-(propan-2-yl)benzamide
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC12H17N3O3S
Molar mass283.35 g·mol−1
3D model (JSmol)
  • O=S(=O)(c1cc(ccc1C(C)C)C(=O)/N=C(\N)N)C
  • InChI=1S/C12H17N3O3S/c1-7(2)9-5-4-8(11(16)15-12(13)14)6-10(9)19(3,17)18/h4-7H,1-3H3,(H4,13,14,15,16)
  • Key:IWXNYAIICFKCTM-UHFFFAOYSA-N

Cariporide is a selective Na+/H+ exchange inhibitor. Cariporide has been shown to actively suppress the cell death caused by oxidative stress.[1]

Cariporide is a potent NHE1 inhibitor is may also be useful for treatment of cancer.[2]

  1. ^ Teshima Y, Akao M, Jones SP, Marbán E (November 2003). "Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway". Circulation. 108 (18): 2275–81. doi:10.1161/01.CIR.0000093277.20968.C7. PMID 14568900.
  2. ^ Harguindey S, Arranz JL, Polo Orozco JD, Rauch C, Fais S, Cardone RA, Reshkin SJ (November 2013). "Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research". Journal of Translational Medicine. 11 (1): 282. doi:10.1186/1479-5876-11-282. PMC 3826530. PMID 24195657.